Ann Vos

Janssen (Belgium) — Belgium

Chemistry · Physical Sciences

21h-index1.7kcitations49works4.52yr avg
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Research Topics

Zeolite Catalysis and Synthesis(13), Advanced Chemical Physics Studies(9), Computational Drug Discovery Methods(9), HIV/AIDS drug development and treatment(7), Catalysis and Oxidation Reactions(6)

Publications49 total

In Pursuit of Best-in-Class MCL-1 Inhibitors: Discovery of Highly Potent 1,4-Indoyl Macrocycles with Favorable Physicochemical Properties
Journal of Medicinal Chemistry·2025
Targeting de novo purine biosynthesis for tuberculosis treatment
Nature·2025· 15 citedOpen Access
Targeting de novo purine biosynthesis for tuberculosis treatment
2024Open Access
Quantum extremal learning
Quantum Machine Intelligence·2024· 3 cited
Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1
ACS Medicinal Chemistry Letters·2023· 10 citedOpen Access
Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein–Protein Interaction Modulator with the Potential of Treating Hematological Malignancies
Journal of Medicinal Chemistry·2023· 23 cited
Abstract 2133: In pursuit of MCL-1 inhibitors with improved therapeutic window for the treatment of hematological malignancies: Discovery of JNJ-4355
Cancer Research·2022· 8 cited
Quantum Extremal Learning
arXiv (Cornell University)·2022Open Access
Divide and Conquer. Pocket-Opening Mixed-Solvent Simulations in the Perspective of Docking Virtual Screening Applications for Drug Discovery
Journal of Chemical Information and Modeling·2022· 11 citedOpen Access
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo
ACS Medicinal Chemistry Letters·2021· 8 citedOpen Access
Modulating physicochemical properties of tetrahydropyridine-2-amine BACE1 inhibitors with electron-withdrawing groups: A systematic study
European Journal of Medicinal Chemistry·2021· 5 citedOpen Access
JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate
Journal of Medicinal Chemistry·2021· 18 citedOpen Access
Development and Implementation of an enterprise-wide Predictive Model for Early absorption, distribution, Metabolism and Excretion Properties
Future Medicinal Chemistry·2021· 21 citedOpen Access
Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1<i>H</i>-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2<i>H</i>-imidazo[4,5-<i>c</i>]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus
Journal of Medicinal Chemistry·2020· 27 citedOpen Access
CCDC 1948923: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
3,3-Difluoro-3,4,5,6-tetrahydropyridin-2-amines: Potent and permeable BACE-1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2020· 3 citedOpen Access
Preparation of 4′‐Spirocyclobutyl Nucleoside Analogues as Novel and Versatile Adenosine Scaffolds
Chemistry - A European Journal·2019· 13 cited
Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads
ACS Medicinal Chemistry Letters·2019· 33 citedOpen Access
Minisci-Photoredox-Mediated α-Heteroarylation of N-Protected Secondary Amines: Remarkable Selectivity of Azetidines
Organic Letters·2018· 74 cited
Synthesis and Evaluation of <i>N</i>-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV)
Journal of Medicinal Chemistry·2018· 50 citedOpen Access
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Frequent Co-authors

Robert A. Schoonheydt(15), Paul Geerlings(12), Frederik Rombouts(11), Gary Tresadern(7), Aldo Peschiulli(7), Harrie J. M. Gijsen(6), Maxwell D. Cummings(5), Frank De Proft(5), Michel Surkyn(5), Michel De Cleyn(5), R. Clayton(4), Daniel Oehlrich(4), Nigel Austin(4), Sven Van Brandt(4), Andrés A. Trabanco(4), Herman van Vlijmen(4), Maria Dominguez Blanco(4), Mariette Bekkers(4), Seong Joo Koo(4), Ulrike Philippar(4)