Domenico D’Arca

University of Modena and Reggio Emilia — Italy

Medicine · Health Sciences

19h-index2.1kcitations60works3.32yr avg
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Research Topics

Colorectal Cancer Treatments and Studies(12), Biochemical and Molecular Research(12), Clusterin in disease pathology(11), Cancer, Lipids, and Metabolism(7), Cancer, Hypoxia, and Metabolism(6)

Publications60 total

Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics
European Journal of Medicinal Chemistry·2025· 1 citedOpen Access
Abstract P04: TARGETING THYMIDYLATE SYNTHASE (HTS) SUPPRESSES COLORECTAL CANCER CELL GROWTH BY INDUCING DNA DAMAGE AND APOPTOSIS
Cancer Research·2025
Gut microbial metabolites of phenolic compounds inhibit colon cancer cell proliferation by triggering apoptosis and cell cycle arrest
Food & Function·2025· 6 cited
Bioaccessibility of Flavones, Flavanones, and Flavonols from Vegetable Foods and Beverages
Biology·2024· 9 citedOpen Access
Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation
Frontiers in Pharmacology·2024· 4 citedOpen Access
Optical tweezers to investigate at the single-molecule level the interaction of thymidylate synthase with its consensus mRNA
2024
Targeting the Interplay of Independent Cellular Pathways and Immunity: A Challenge in Cancer Immunotherapy
Cancers·2023· 8 citedOpen Access
Serum Mass Spectrometry Proteomics and Protein Set Identification in Response to FOLFOX-4 in Drug-Resistant Ovarian Carcinoma
Cancers·2023· 7 citedOpen Access
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth
eLife·2022· 13 citedOpen Access
Author response: Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth
2022Open Access
Telomere Dysfunction Is Associated with Altered DNA Organization in Trichoplein/Tchp/Mitostatin (TpMs) Depleted Cells
Biomedicines·2022· 5 citedOpen Access
Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library
Pharmaceutics·2022· 7 citedOpen Access
Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations
Cancers·2021· 4 citedOpen Access
Folic Acid–Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting
Journal of Medicinal Chemistry·2021· 27 citedOpen Access
Disrupters of the Thymidylate Synthase Homodimer Accelerate Its Proteasomal Degradation and Inhibit Cancer Growth.
2021Open Access
Disrupters of the Thymidylate Synthase Homodimer Accelerate Its Proteasomal Degradation and Inhibit Cancer Growth.
2021· 1 citedOpen Access
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells
International Journal of Molecular Sciences·2020· 7 citedOpen Access
Trichoplein binds <scp>PCM</scp> 1 and controls endothelial cell function by regulating autophagy
EMBO Reports·2020· 30 citedOpen Access
Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells
Cancers·2020· 12 citedOpen Access
The 1,10-Phenanthroline Ligand Enhances the Antiproliferative Activity of DNA-Intercalating Thiourea-Pd(II) and -Pt(II) Complexes Against Cisplatin-Sensitive and -Resistant Human Ovarian Cancer Cell Lines
International Journal of Molecular Sciences·2019· 22 citedOpen Access
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Frequent Co-authors

Gaetano Marverti(25), Maria Paola Costi(23), Angela Lauriola(20), Andrea Caporali(19), Glauco Ponterini(16), Lorena Losi(14), Stefania Ferrari(13), Matteo Santucci(11), Salvatore Pacifico(11), Pierpaola Davalli(9), Saverio Bettuzzi(9), Renzo Guerrini(9), Gaia Gozzi(9), S Astancolle(8), Chiara Marraccini(8), Andrea Martello(7), Lorenzo Tagliazucchi(7), Rosaria Luciani(7), Maurizio Scaltriti(6), Leda Severi(6)