Viktor Brabec

Czech Academy of Sciences — Czech Republic

Medicine · Health Sciences

67h-index17.0kcitations583works3.82yr avg
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Research Topics

Metal complexes synthesis and properties(277), DNA and Nucleic Acid Chemistry(208), Ferrocene Chemistry and Applications(133), Advanced biosensing and bioanalysis techniques(95), X-ray Diffraction in Crystallography(81)

Publications583 total

Photocatalytic arylterpyridine iridium( <scp>iii</scp> ) complexes trigger oncosis in 2D and 3D cancer cell models <i>via</i> NADH oxidation
Inorganic Chemistry Frontiers·2025Open Access
Crizotinib- or Ceritinib-Conjugated Platinum(IV) Prodrugs As Potent Multiaction Agents Inducing Antiproliferative Effects in 2D and 3D Cancer Cell Models
Journal of Medicinal Chemistry·2025· 1 citedOpen Access
Platinum(IV) oxaliplatin analog containing axial benzoate ligands induces mitochondrial hyperpolarization and caspase-dependent apoptosis in pancreatic cancer cell models
Chemico-Biological Interactions·2025
Phototoxicity of Half-Sandwich Rhodium(III) Complexes with Anthracene and Biphenyl Substituents toward Mammalian Cancer Cells and Multicellular Tumor Spheroids
Journal of Medicinal Chemistry·2025· 2 citedOpen Access
Photoactivatable Cyclometalated Ir(III) Compound Penetrates the Blood-Brain Barrier in 3D Spheroidal and Advanced 3D Organoid Models of Inherently Resistant and Aggressive Brain Tumors
ACS Pharmacology & Translational Science·2025· 2 citedOpen Access
Excited-State <i>Cis</i> and <i>Trans</i> Pt(IV) Diamine Anticancer Complexes
Inorganic Chemistry·2025· 2 citedOpen Access
Antitumor platinum(II) complex 56MESS binds to DNA G-quadruplexes, downregulates expression of c-MYC and k-RAS oncogenes, and triggers DNA damage in cancer cells
Chemico-Biological Interactions·2025· 1 cited
Cisplatin-eugenol Pt(IV) prodrugs target colon cancer stem cells: A novel strategy for enhanced anticancer efficacy
Biomedicine & Pharmacotherapy·2025· 1 citedOpen Access
A novel benzothiazole-1,2,3-triazole-based arene osmium(<scp>ii</scp>) complex as an effective rhabdomyosarcoma cancer stem cell agent
Inorganic Chemistry Frontiers·2025· 8 citedOpen Access
A Novel Substituted Benzo[<i>g</i>]quinoxaline-Based Cyclometalated Ru(II) Complex as a Biocompatible Membrane-Targeted PDT Colon Cancer Stem Cell Agent
Journal of Medicinal Chemistry·2024· 10 citedOpen Access
Ni(II) Cylinders Damage DNA in Cancer Cells and Preferentially Bind Y‐Shaped DNA Three‐Way Junctions Blocking DNA Synthesis
Small·2024Open Access
Antimetastatic activity of (arene)ruthenium(II) complex of 4-aryl-4H-naphthopyran
Chemico-Biological Interactions·2024· 2 cited
Multiaction Pt(IV) Prodrugs Releasing Cisplatin and Dasatinib Are Potent Anticancer and Anti-Invasive Agents Displaying Synergism between the Two Drugs
Journal of Medicinal Chemistry·2024· 8 cited
Interaction of dinuclear Co(III) cylinders with higher-order DNA structures
Chemico-Biological Interactions·2024· 6 cited
Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells
Chemico-Biological Interactions·2024· 5 cited
New cyclometalated Ru(<scp>ii</scp>) polypyridyl photosensitizers trigger oncosis in cancer cells by inducing damage to cellular membranes
Inorganic Chemistry Frontiers·2024· 12 citedOpen Access
Dicobalt(<scp>ii</scp>) helices kill colon cancer cells <i>via</i> enantiomer-specific mechanisms; DNA damage or microtubule disruption
Chemical Science·2024· 4 citedOpen Access
Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis
Journal of Medicinal Chemistry·2023· 45 citedOpen Access
Book review
Transition Metal Chemistry·2023
N-Indolyl diiron vinyliminium complexes exhibit antiproliferative effects in cancer cells associated with disruption of mitochondrial homeostasis, ROS scavenging, and antioxidant activity
Chemico-Biological Interactions·2023· 13 citedOpen Access
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Frequent Co-authors

Jana Kašpárková(23), Olga Nováková(15), Peter J. Sadler(13), Nicholas P. Farrell(6), Abraha Habtemariam(5), Oldřich Vrána(5), Ana M. Pizarro(4), Guy J. Clarkson(4), Simon Parsons(4), Vojtěch Novohradský(4), Hana Kostrhunová(4), Luca Salassa(3), Jaroslav Malina(3), Dan Gibson(3), Jana Štěpánková(3), Zhe Liu(2), Anna Kisova(2), Haimei Chen(2), Alison Rodger(2), Julie A. Woods(2)