Sighild Lemarchant

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index680citations30works3.02yr avg
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Research Topics

Protease and Inhibitor Mechanisms(6), Nerve injury and regeneration(5), Spinal Cord Injury Research(5), Osteoarthritis Treatment and Mechanisms(4), Neuroinflammation and Neurodegeneration Mechanisms(4)

Publications30 total

SCO-Spondin-Derived Peptide NX210 Promotes Functional Recovery after Spinal Cord Injury in Mice
Journal of Neurotrauma·2025· 1 cited
Administration of a Novel Peptide Derived From Thrombospondin Repeat Sequences Enhances Recovery after Cervical Spinal Cord Injury
Journal of Neurotrauma·2025
Blood-spinal cord barrier alterations in a mouse model of centrifugation-induced hypergravity
Frontiers in Physiology·2025Open Access
Restoring brain barriers: an innovative approach for treating neurological disorders
Fluids and Barriers of the CNS·2025· 7 citedOpen Access
Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study
Neurology and Therapy·2024· 4 citedOpen Access
NX210c drug candidate peptide strengthens mouse and human blood-brain barriers
Fluids and Barriers of the CNS·2024· 6 citedOpen Access
Student Competition (Knowledge Generation) ID 1987946
Topics in Spinal Cord Injury Rehabilitation·2023Open Access
NX210c Peptide Promotes Glutamatergic Receptor-Mediated Synaptic Transmission and Signaling in the Mouse Central Nervous System
International Journal of Molecular Sciences·2022· 10 citedOpen Access
Safety, Tolerability, Pharmacokinetics and Initial Pharmacodynamics of a Subcommissural Organ-Spondin-Derived Peptide: A Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose First-in-Human Study
Neurology and Therapy·2022· 11 citedOpen Access
Subcommissural Organ-Spondin-Derived Peptide Restores Memory in a Mouse Model of Alzheimer’s Disease
Frontiers in Neuroscience·2021· 14 citedOpen Access
SCO-spondin-derived Peptide Protects Neurons from Glutamate-induced Excitotoxicity
Neuroscience·2021· 23 citedOpen Access
Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR‐127 in aged animals
Aging Cell·2020· 15 citedOpen Access
Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation
Journal of Neuroinflammation·2017· 33 citedOpen Access
Early to Long-Term Alterations of CNS Barriers After Traumatic Brain Injury: Considerations for Drug Development
The AAPS Journal·2017· 24 cited
Relevance of the Proteolytic Processing of Reelin by ADAMTS-3 in Brain Functions
Journal of Neuroscience·2017· 1 citedOpen Access
ADAMTS‐4 in central nervous system pathologies
Journal of Neuroscience Research·2017· 15 cited
Lack of collagen XV is protective after ischemic stroke in mice
Cell Death and Disease·2017· 12 citedOpen Access
Brain Edema Formation in Traumatic Brain Injury
Elsevier eBooks·2017· 7 cited
List of Contributors
Elsevier eBooks·2017
Perineuronal nets in neurodegeneration
Oncotarget·2016· 9 citedOpen Access
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Frequent Co-authors

Jari Koıstınaho(12), Yann Godfrin(10), Katja M. Kanninen(9), Tarja Malm(8), Denis Vivien(6), Hiramani Dhungana(5), Paula Korhonen(4), Sara Wojciechowski(4), Joan Montaner(4), Évelyne Emery(4), Gundars Goldsteins(4), Juliette Le Douce(4), Šárka Lehtonen(3), Sanna Loppi(3), Iurii Kidin(3), Teresa García‐Berrocoso(3), Yuriy Pomeshchik(3), Mikko T. Huuskonen(3), Piia Valonen(3), Jérôme Badaut(3)