Rowena Sison‐Young

University of Liverpool — United Kingdom

Medicine · Health Sciences

18h-index2.2kcitations31works2.32yr avg
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Research Topics

Liver physiology and pathology(13), Pharmacogenetics and Drug Metabolism(12), Drug-Induced Hepatotoxicity and Protection(12), Pluripotent Stem Cells Research(5), Drug Transport and Resistance Mechanisms(5)

Publications31 total

Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety
Nature Reviews Drug Discovery·2025· 2 cited
Response to “Acetaminophen should be a critical reference hepatotoxin for evaluating human-relevant in vitro models”
Toxicological Sciences·2024Open Access
Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models
Toxicological Sciences·2024· 5 citedOpen Access
A systems approach reveals species differences in hepatic stress response capacity
Toxicological Sciences·2023· 13 citedOpen Access
Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System
Chemical Research in Toxicology·2023· 10 citedOpen Access
Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury
Toxicological Sciences·2023· 11 citedOpen Access
A systems approach reveals species differences in hepatic stress response capacity
2022· 1 citedOpen Access
Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration
Hepatology·2021· 50 citedOpen Access
Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process
Molecular Pharmaceutics·2018· 40 cited
Model-based identification of TNF alpha-induced IKK beta-mediated and I kappa B alpha-mediated regulation of NF kappa B signal transduction as a tool to quantify the impact of drug-induced liver injury compounds
2018· 1 cited
Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds
npj Systems Biology and Applications·2018· 22 citedOpen Access
Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms
Archives of Toxicology·2018· 51 citedOpen Access
Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study
Toxicological Sciences·2018· 297 citedOpen Access
Expression and enzyme activity of cytochrome P450 enzymes <scp>CYP</scp>3A4 and <scp>CYP</scp>3A5 in human skin and tissue‐engineered skin equivalents
Experimental Dermatology·2017· 13 citedOpen Access
Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins
Toxicology in Vitro·2017· 34 cited
Donor-Dependent and Other Nondefined Factors have Greater Influence on the Hepatic Phenotype than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells
Stem Cells Translational Medicine·2017· 5 citedOpen Access
Issue Information
Stem Cells Translational Medicine·2017Open Access
Donor-Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells
Stem Cells Translational Medicine·2017· 18 citedOpen Access
Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development
Elsevier eBooks·2017· 5 cited
Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation
Hepatology·2016· 115 citedOpen Access
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Frequent Co-authors

Christopher E. Goldring(29), Neil R. Kitteringham(12), B. Kevin Park(11), Stephen W. Fenwick(9), Magnus Ingelman‐Sundberg(7), Hassan Malik(7), James A. Heslop(7), Richard Kia(7), Robert Jones(7), Richard Weaver(6), Ian M. Copple(6), Rosalind E. Jenkins(5), Cliff Rowe(5), Mohamed Elmasry(5), James E. Sidaway(5), Dean J. Naisbitt(5), Bob van de Water(5), Lucia A Livoti(5), Ciarán Fisher(5), Volker M. Lauschke(4)