Jean‐Philippe Gagné

Centre hospitalier universitaire de Québec — Canada

Medicine · Health Sciences

29h-index3.5kcitations90works4.62yr avg
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Research Topics

PARP inhibition in cancer therapy(40), DNA Repair Mechanisms(36), CRISPR and Genetic Engineering(11), Microtubule and mitosis dynamics(10), Toxin Mechanisms and Immunotoxins(9)

Publications90 total

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels
Nature Communications·2025Open Access
CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair
Nature Communications·2025· 2 citedOpen Access
Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels
2025· 1 cited
Proteomic study identifies Aurora-A–mediated regulation of alternative splicing through multiple splicing factors
Journal of Biological Chemistry·2024· 11 citedOpen Access
pADP-ribosylation regulates the cytoplasmic localization, cleavage, and pro-apoptotic function of HuR
Life Science Alliance·2024· 2 citedOpen Access
Poly( <scp>ADP</scp> ‐ribose) mediates bioenergetic defects and redox imbalance in neurons following oxygen and glucose deprivation
The FASEB Journal·2024· 10 citedOpen Access
Tankyrase-1 regulates RBP-mediated mRNA turnover to promote muscle fiber formation
Nucleic Acids Research·2024· 6 citedOpen Access
ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance
Nucleic Acids Research·2023· 12 citedOpen Access
pADP-ribosylation Regulates the Cytoplasmic Localization, Cleavage and Pro-apoptotic Function of HuR
2023Open Access
The dynamic process of covalent and non-covalent PARylation in the maintenance of genome integrity: a focus on PARP inhibitors
NAR Cancer·2023· 9 citedOpen Access
Poly(ADP-ribose) mediates bioenergetic defects and redox imbalance in neurons following oxygen and glucose deprivation
2023· 1 citedOpen Access
Supplementary Table 1 from Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
2023Open Access
Supplementary Figure 1 from Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
2023Open Access
Supplementary Table 2 from Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
2023Open Access
Supplementary Table 1 from Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
2023Open Access
Supplementary Figure 5 from Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
2023Open Access
Supplementary Figure 3 from Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
2023Open Access
Supplementary Figure 6 from Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
2023Open Access
Supplementary Figure 5 from Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
2023Open Access
Data from Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
2023Open Access
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Frequent Co-authors

Guy G. Poirier(50), Michael J. Hendzel(13), Jean‐Yves Masson(9), Chantal Éthier(6), John M. Pascal(5), Marie‐Christine Caron(5), Pierre Gagné(5), Arnaud Droit(5), Yan Coulombe(4), Marie-France Langelier(4), Maxim Isabelle(4), Louis Nonfoux(4), Marie-Ève Bonicalzi(4), Valina L. Dawson(3), Anthony R. Fehr(3), Ismail Hassan Ismail(3), Julia O’Sullivan(3), Émilie Pic(3), Isabelle Kelly(3), Michèle Rouleau(3)