Mark J. Majchrzak

University of Rhode Island — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index2.1kcitations60works1.02yr avg
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Research Topics

Nicotinic Acetylcholine Receptors Study(15), Neurotransmitter Receptor Influence on Behavior(13), Neuroscience and Neuropharmacology Research(12), Receptor Mechanisms and Signaling(11), Memory and Neural Mechanisms(9)

Publications60 total

Parenchymal and Dyshoric Fibrillar Amyloid Pathology in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2
American Journal Of Pathology·2025Open Access
Implications of packed red bloods cells production and transfer on post transfusion hemoglobin increase
Journal of Clinical Anesthesia·2025
A novel gene edited rat model of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)
Cerebral Circulation - Cognition and Behavior·2025Open Access
A Novel Gene Edited Rat Model of Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (Carasil)
SSRN Electronic Journal·2025Open Access
Cerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments
Neuroscience Insights·2024· 5 citedOpen Access
Sex Differences in Metabolic Indices and Chronic Neuroinflammation in Response to Prolonged High-Fat Diet in ApoE4 Knock-In Mice
International Journal of Molecular Sciences·2022· 26 citedOpen Access
Impact of Non-pharmacological Chronic Hypertension on a Transgenic Rat Model of Cerebral Amyloid Angiopathy
Frontiers in Neuroscience·2022· 14 citedOpen Access
Short-term treatment with dabigatran alters protein expression patterns in a late-stage tau-based Alzheimer's disease mouse model
Biochemistry and Biophysics Reports·2020· 15 citedOpen Access
P3‐181: TREATMENT WITH THE DIRECT THROMBIN INHIBITOR DABIGATRAN ETEXILATE REDUCES OXIDATIVE STRESS <i>IN VIVO</i> IN A MOUSE MODEL OF ALZHEIMER'S DISEASE
Alzheimer s & Dementia·2019Open Access
Dramatic elevation in urinary amino terminal titin fragment excretion quantified by immunoassay in Duchenne muscular dystrophy patients and in dystrophin deficient rodents
Neuromuscular Disorders·2017· 40 citedOpen Access
Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects
ACS Chemical Neuroscience·2016· 23 citedOpen Access
Peripheral Administration of a Long-Acting Peptide Oxytocin Receptor Agonist Inhibits Fear-Induced Freezing
Journal of Pharmacology and Experimental Therapeutics·2016· 30 citedOpen Access
Pharmacological disruption of mouse social approach behavior: Relevance to negative symptoms of schizophrenia
Behavioural Brain Research·2013· 36 cited
Phosphodiesterase 9A Regulates Central cGMP and Modulates Responses to Cholinergic and Monoaminergic Perturbation In Vivo
Journal of Pharmacology and Experimental Therapeutics·2012· 79 cited
Modulation of NMDA receptor function by inhibition of d-amino acid oxidase in rodent brain
Neuropharmacology·2011· 40 cited
CCDC 782385: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
A novel series of [3.2.1] azabicyclic biaryl ethers as α3β4 and α6/4β4 nicotinic receptor agonists
Bioorganic & Medicinal Chemistry Letters·2010· 10 citedOpen Access
P3‐380: Dendritic spine density deficits in the hippocampal CA1 region of young Tg2576 mice are ameliorated with the PDE9A inhibitor PF‐04447943
Alzheimer s & Dementia·2010· 15 citedOpen Access
Preclinical pharmacology of the α4β2 nAChR partial agonist varenicline related to effects on reward, mood and cognition
Biochemical Pharmacology·2009· 115 cited
Preclinical Characterization of Selective Phosphodiesterase 10A Inhibitors: A New Therapeutic Approach to the Treatment of Schizophrenia
Journal of Pharmacology and Experimental Therapeutics·2008· 284 cited
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Frequent Co-authors

Steven C. Dilsaver(12), Michael Decker(7), Patricia A. Seymour(6), Cynthia S. Pomerleau(6), Ovide F. Pomerleau(6), Blake A. Gosnell(5), Mihály Hajós(4), F. David Tingley(4), Bruno Will(4), Patrick R. Verhoest(3), David J. Anderson(3), Dean D. Krahn(3), Victor Guanowsky(3), Stephen P. Arnerić(3), Michelle Vanase‐Frawley(3), Christopher J. Schmidt(3), Douglas S. Chapin(2), John F. Harms(2), Fredrick R. Nelson(2), Andres D. Ramirez(2)