Andrew Best

Newcastle University — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index2.8kcitations29works7.02yr avg
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Research Topics

RNA Research and Splicing(12), RNA and protein synthesis mechanisms(10), RNA modifications and cancer(9), CAR-T cell therapy research(9), Immunotherapy and Immune Responses(7)

Publications29 total

An ultra-conserved poison exon in the Tra2b gene encoding a splicing activator is essential for male fertility and meiotic cell division
The EMBO Journal·2025· 4 citedOpen Access
High-throughput sensitive screening of small molecule modulators of microexon alternative splicing using dual Nano and Firefly luciferase reporters
Nature Communications·2024· 10 citedOpen Access
Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis
Molecular Cell·2022· 25 citedOpen Access
104 Development and characterization of human chimeric antigen receptor monocytes (CAR-Mono), a novel cell therapy platform
Regular and Young Investigator Award Abstracts·2021· 3 citedOpen Access
Abstract 1530: Anti-HER2 CAR monocytes demonstrate targeted anti-tumor activity and enable a single day cell manufacturing process
Cancer Research·2021· 11 cited
Abstract 2180: Genetically engineered chimeric antigen receptor (CAR) monocytes demonstrate targeted anti-tumor activity and differentiate into M1-polarized CAR macrophages
Cancer Research·2020· 4 cited
Abstract 3242: CT-0508 is an anti-HER2 chimeric antigen receptor (CAR) macrophage with targeted anti-tumor activity that promotes a pro-inflammatory solid tumor microenvironment
Cancer Research·2020· 3 cited
Abstract PR07: Human chimeric antigen receptor (CAR) macrophages for cancer immunotherapy
Cancer Immunology Research·2020· 3 cited
Human chimeric antigen receptor macrophages for cancer immunotherapy
Nature Biotechnology·2020· 1.3k citedOpen Access
Abstract B65: CT-0508, a novel CAR macrophage product directed against HER2, promotes a proinflammatory tumor microenvironment
Cancer Immunology Research·2020· 5 cited
Genome-wide CRISPR-Cas9 Interrogation of Splicing Networks Reveals a Mechanism for Recognition of Autism-Misregulated Neuronal Microexons
Molecular Cell·2018· 133 citedOpen Access
Efficient and Accurate Quantitative Profiling of Alternative Splicing Patterns of Any Complexity on a Laptop
Molecular Cell·2018· 198 cited
<i>Whippet</i> : an efficient method for the detection and quantification of alternative splicing reveals extensive transcriptomic complexity
2017· 13 citedOpen Access
First in-depth investigation of multiple inhibitory molecule expression by bona fide tumor-reactive T cells in ovarian cancer.
The Journal of Immunology·2016
Abstract A49: Investigating the expression of inhibitory surface molecules in ovarian cancer tumor-infiltrating lymphocytes.
Clinical Cancer Research·2016
Evaluating the Measurement Structure of the Abbreviated HIV Stigma Scale in a Sample of African Americans Living With HIV/AIDS
Rehabilitation Research Policy and Education·2016· 17 cited
Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive splicing of checkpoint kinase 1
Frontiers of Chemical Science and Engineering·2015· 3 cited
Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells
BioMed Research International·2015· 11 citedOpen Access
Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons
Nature Communications·2014· 69 citedOpen Access
Use of Whole-Exome Sequencing to Determine the Genetic Basis of Multiple Mitochondrial Respiratory Chain Complex Deficiencies
JAMA·2014· 361 citedOpen Access
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Frequent Co-authors

Michael Klichinsky(7), David J. Elliott(7), Daniel J. Powell(6), Maggie Schmierer(5), Saar Gill(5), Benjamin J. Blencowe(5), Olga Shestova(4), Xueqing Maggie Lu(4), Martha Zeeman(4), Konrad Gabrusiewicz(4), Qunrui Ye(4), Caroline Dalgliesh(4), Ingrid Ehrmann(4), Alison Tyson-Capper(4), Yumi Ohtani(4), Nicholas R. Anderson(3), Nicholas Petty(3), Feng Shen(3), Xinhe Shan(3), De-Gang Song(3)