Hung‐wen Liu

American Association of Colleges of Pharmacy — United States

Chemistry · Physical Sciences

59h-index12.1kcitations341works2.62yr avg
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Research Topics

Carbohydrate Chemistry and Synthesis(87), Microbial Natural Products and Biosynthesis(76), Enzyme Structure and Function(58), Biochemical and Molecular Research(54), Metalloenzymes and iron-sulfur proteins(51)

Publications341 total

Refining the Substrate-Cofactor Disposition Model of Hyoscyamine 6β-Hydroxylase Catalysis Using Hyoscyamine Analogs
Journal of the American Chemical Society·2025Open Access
Pyrazofurin Biosynthesis Involves Nonenzymatic Ring Contraction of a Pyridazine Intermediate Triggered by a Rieske Enzyme-Catalyzed Oxygenation
Journal of the American Chemical Society·2025· 1 citedOpen Access
A Selenium-for-Oxygen Swapping Reaction Catalyzed by the Radical <i>S</i> -Adenosyl Methionine Enzyme AbmM
Journal of the American Chemical Society·2025· 1 citedOpen Access
Characterization of C3’ Epimerization of the Thioheptose Core in the Biosynthesis of Albomycin <i>δ</i> <sub>2</sub> Catalyzed by the Radical <i>S</i> -Adenosylmethionine Enzyme AbmJ
ACS Catalysis·2025Open Access
Biosynthesis of the Thiofuranose Core in Albomycin Requires a Versatile Enzyme AbmG That Catalyzes Net Dehydration via Cryptic Phosphorylation
Journal of the American Chemical Society·2025· 2 citedOpen Access
Radical Propagation via σ-Cleavage Mediates Radical SAM Catalyzed Sulfur-for-Oxygen Swapping Reaction during the Biosynthesis of Albomycin δ<sub>2</sub>
Journal of the American Chemical Society·2025· 2 citedOpen Access
Structure-Guided Mechanistic Investigation of Stereochemical Inversion during the Octose Formation Catalyzed by an Atypical Transaldolase AprG in the Biosynthesis of Apramycin
ACS Catalysis·2025
Radical S-adenosyl-l-methionine FeS cluster implicated as the sulfur donor during albomycin biosynthesis
Nature Catalysis·2025· 6 citedOpen Access
A [2.1.0]-Fused Bicyclic Intermediate Is Produced during the Biosynthesis of Oxetane Nucleosides
Journal of the American Chemical Society·2025· 4 cited
Reinvestigation of the <i>C</i>-Glycoside Synthase in Alnumycin Biosynthesis Reveals a Conserved Mechanism of C–C Bond Formation
Journal of the American Chemical Society·2025· 2 citedOpen Access
Author response for "Structural and Mechanistic Insights into KslB, a Bacterial Pictet-Spenglerase in Kitasetaline Biosynthesis"
2025
Revision of the Formycin A and Pyrazofurin Biosynthetic Pathways Reveals Specificity for <scp>d</scp>-Glutamic Acid and a Cryptic <i>N</i>-Acylation Step During Pyrazole Core Formation
Journal of the American Chemical Society·2025· 8 citedOpen Access
Blasticidin S Biosynthesis Involves a Unique Interplay between a Radical SAM Dehydratase, a Transaminase and an ATP-Grasp Ligase in Order to Avoid a Futile Cycle
ACS Catalysis·2025· 3 citedOpen Access
EPR Characterization of the BlsE Substrate Radical Offers Insight into the Determinants of Reaction Outcome that Distinguish Radical SAM Dioldehydratases from Dehydrogenases
Journal of the American Chemical Society·2025· 6 citedOpen Access
Radical <i>S</i>-Adenosylmethionine Sulfurtransferase MybB Catalyzed Formation of the 4-Thiazolidinone Core in Mycobacidin Represents an Intersection between Primary and Secondary Metabolism
Journal of the American Chemical Society·2025· 6 citedOpen Access
Correction to “Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical <i>S</i>-Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase”
Journal of the American Chemical Society·2025
Structural and mechanistic insights into KslB, a bacterial Pictet–Spenglerase in kitasetaline biosynthesis
RSC Chemical Biology·2025· 3 citedOpen Access
Initiation, Propagation, and Termination in the Chemistry of Radical SAM Enzymes
Biochemistry·2024· 11 citedOpen Access
In Vitro Characterization of Kitasetaline Biosynthesis Reveals a Bifunctional P450 Decarboxylase and a Vinyl β-Carboline Intermediate Susceptible to Nonenzymatic Thiol Addition
Journal of the American Chemical Society·2024· 1 cited
Biosynthesis of the Unusual Epoxy Isonitrile-Containing Antibiotics Aerocyanidin and Amycomicin
Journal of the American Chemical Society·2024· 5 citedOpen Access
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Frequent Co-authors

Lishan Zhao(8), Charles E. Melançon(5), David H. Sherman(5), Christopher J. Thibodeaux(4), Wei‐chen Chang(4), Pinghua Liu(4), Hak Joong Kim(4), Reid M. McCarty(4), Yongquan Xue(3), Mark W. Ruszczycky(3), Yung-nan Liu(3), Jon S. Thorson(3), Steven O. Mansoorabadi(3), Svetlana A. Borisova(3), Zhihua Tao(2), Peng Gao(2), Gautam Agnihotri(2), Xuemei He(2), Hak Joong Kim(2), Yasushi Ogasawara(2)