Wei‐chen Chang

North Carolina State University — United States

Chemistry · Physical Sciences

33h-index3.8kcitations137works3.22yr avg
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Research Topics

Metal-Catalyzed Oxygenation Mechanisms(70), Metalloenzymes and iron-sulfur proteins(29), Microbial Natural Products and Biosynthesis(22), Plant biochemistry and biosynthesis(17), Enzyme Catalysis and Immobilization(14)

Publications137 total

Correction to “Regio- and Stereoselective Halogenation by an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase in the Biosynthesis of Halogenated Nucleosides”
Journal of the American Chemical Society·2026Open Access
The Mosher Method in the Study of Natural Products
ACS in focus·2025
Regio- and Stereoselective Halogenation by an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase in the Biosynthesis of Halogenated Nucleosides
Journal of the American Chemical Society·2025Open Access
Correction to “Discovery and Mechanism of a Diiron Enzyme in Ethylidene Azetidine Formation”
Journal of the American Chemical Society·2025
Mechanistic and Structural Analyses of Non-Heme Iron Enzyme TqaM for α-Tertiary Amino Acid Synthesis
Journal of the American Chemical Society·2025
Discovery and Mechanism of a Diiron Enzyme in Ethylidene Azetidine Formation
Journal of the American Chemical Society·2025· 1 citedOpen Access
Testing the Luedemann hypothesis: the discovery of novel antimicrobials from slow-growing microbes from nutrient-limited environments
mSphere·2025Open Access
Provision of a Redox Donor to Oxy-Ferrous PrnB Is Required for Pyrrolnitrin Synthesis
Biochemistry·2025
Multiple Catalytic Branch Points in the Mechanism of Pyrrolidine Formation During Kainoid Biosynthesis Leads to Diverse Reaction Outcomes
Journal of the American Chemical Society·2025· 2 citedOpen Access
Studies of Isonitrile Synthases Help Elucidate the Mechanism of Isonitrile Installation
ACS Catalysis·2025· 3 citedOpen Access
An Alternative Mechanism for C–C Desaturation Underscores a Dual-Controlled Mechanism for the Fate of Radical Intermediate in Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenase DfmD
Journal of the American Chemical Society·2025· 5 cited
Beyond the β–α–β Fold: Characterization of a SnoaL Domain in the Tautomerase Superfamily
Biochemistry·2025· 1 cited
Discovery of Noncanonical Iron and 2-Oxoglutarate Dependent Enzymes Involved in C–C and C–N Bond Formation in Biosynthetic Pathways
ACS Bio & Med Chem Au·2025· 5 citedOpen Access
Comparison of a Nonheme Iron Cyclopropanase with a Homologous Hydroxylase Reveals Mechanistic Features Associated with Distinct Reaction Outcomes
Journal of the American Chemical Society·2025· 6 citedOpen Access
Bioinformatic, structural, and biochemical analysis leads to the discovery of novel isonitrilases and decodes their substrate selectivity
RSC Chemical Biology·2025· 1 citedOpen Access
Optimized Substrate Positioning Enables Switches in the C–H Cleavage Site and Reaction Outcome in the Hydroxylation–Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase
Journal of the American Chemical Society·2024· 20 citedOpen Access
New Frontiers in Nonheme Enzymatic Oxyferryl Species
ChemBioChem·2024· 7 citedOpen Access
Antiviral activity and underlying mechanisms of baicalin against porcine reproductive and respiratory syndrome virus in vitro
Microbial Pathogenesis·2024· 8 cited
A survey of C–C bond formation strategies and mechanism deployed by iron-containing enzymes in natural products
Tetrahedron·2024· 5 cited
Optimized Substrate Positioning Enables Switches in C–H Cleavage Site and Reaction Outcome in the Hydroxylation-Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase
2024· 1 citedOpen Access
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Frequent Co-authors

Yisong Guo(19), Carsten Krebs(15), J. Martin Bollinger(15), Hung‐wen Liu(14), Amie K. Boal(8), Yijie Tang(7), Lide Cha(7), Ryan J. Martinie(5), Alexey Silakov(5), Lauren J. Rajakovich(5), Maria‐Eirini Pandelia(5), Steven O. Mansoorabadi(5), Tzu‐Yu Chen(5), Pinghua Liu(4), Christopher J. Thibodeaux(4), Andrew J. Mitchell(4), Bo Zhang(4), Jhih‐Liang Huang(4), Nei‐Li Chan(4), Hao‐Yu Tang(4)