Robert M. Knabb

Bristol-Myers Squibb (Germany) — Germany

Medicine · Health Sciences

41h-index5.5kcitations123works0.02yr avg
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Research Topics

Blood Coagulation and Thrombosis Mechanisms(73), Atrial Fibrillation Management and Outcomes(32), Coagulation, Bradykinin, Polyphosphates, and Angioedema(21), Venous Thromboembolism Diagnosis and Management(15), Protease and Inhibitor Mechanisms(14)

Publications123 total

Discussion of talks from the symposium: Factor X: From thrombokinase to oral anti-coagulants and beyond
Journal of Thrombosis and Thrombolysis·2021Open Access
From basic science to life-saving therapy: the rationale, and drug discovery efforts that led to the direct factor Xa inhibitor eliquis
Journal of Thrombosis and Thrombolysis·2021· 1 cited
First‐in‐human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS‐962212, a direct, reversible, small molecule factor XIa inhibitor in non‐Japanese and Japanese healthy subjects
British Journal of Clinical Pharmacology·2018· 51 citedOpen Access
Apixaban Versus Warfarin for Mechanical Heart Valve Thromboprophylaxis in a Swine Aortic Heterotopic Valve Model
Arteriosclerosis Thrombosis and Vascular Biology·2017· 39 cited
Development of apixaban: a novel anticoagulant for prevention of stroke in patients with atrial fibrillation
Annals of the New York Academy of Sciences·2014· 24 citedOpen Access
Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties
Bioorganic & Medicinal Chemistry Letters·2014· 10 citedOpen Access
Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors
ACS Medicinal Chemistry Letters·2013· 19 citedOpen Access
Nonbenzamidine acylsulfonamide tissue factor–factor VIIa inhibitors
Bioorganic & Medicinal Chemistry Letters·2013· 16 citedOpen Access
Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor
Bioorganic & Medicinal Chemistry Letters·2013· 27 citedOpen Access
Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF–FVIIa inhibitors
Bioorganic & Medicinal Chemistry Letters·2013· 11 citedOpen Access
The emergence of factor Xa inhibitors for the treatment of cardiovascular diseases: a patent review
Expert Opinion on Therapeutic Patents·2012· 16 cited
Abstract 111: Effects of the Novel Factor Xa Inhibitor, Apixaban, on Elevated Levels of Thrombotic Biomarkers in Genetically Obese, Diabetic Mice
Arteriosclerosis Thrombosis and Vascular Biology·2012
A Novel Prothrombin Time Assay for Assessing the Anticoagulant Activity of Oral Factor Xa Inhibitors
Clinical and Applied Thrombosis/Hemostasis·2012· 39 citedOpen Access
Case 34-2011: A Man with Memory Loss and Partial Seizures
2012
Case History
Annual reports in medicinal chemistry·2012· 10 cited
Apixaban versus Enoxaparin for Thromboprophylaxis in Medically Ill Patients
New England Journal of Medicine·2011· 542 citedOpen Access
Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor
European Journal of Drug Metabolism and Pharmacokinetics·2011· 95 cited
Apixaban inhibition of factor Xa: Microscopic rate constants and inhibition mechanism in purified protein systems and in human plasma
Journal of Enzyme Inhibition and Medicinal Chemistry·2010· 42 citedOpen Access
Apixaban decreases coagulation activity in patients with acute deep-vein thrombosis
Thrombosis and Haemostasis·2010· 26 cited
Factor Xa Inhibitors: Next-Generation Antithrombotic Agents
Journal of Medicinal Chemistry·2010· 131 citedOpen Access
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Frequent Co-authors

Ruth R. Wexler(24), Joseph M. Luettgen(18), Donald Pinto(17), Pancras C. Wong(17), Patrick Y. S. Lam(15), Richard Alexander(12), Kan He(10), Karen A. Rossi(9), Mimi L. Quan(9), Angela Smallwood(8), Charles A. Kettner(7), Matthew Wright(7), Michael J. Orwat(6), John M. Fevig(6), James R. Pruitt(6), Keith A.A. Fox(5), Donglu Zhang(5), Robert M. Berne(5), Robert A. Galemmo(5), Alan R. Rendina(4)