Timothy R. Chan

Biogen (United States) — United States

Chemistry · Physical Sciences

7h-index3.4kcitations9works0.02yr avg
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Research Topics

Click Chemistry and Applications(5), Chemical Synthesis and Analysis(4), Neuroscience and Neuropharmacology Research(2), Alzheimer's disease research and treatments(2), Monoclonal and Polyclonal Antibodies Research(2)

Publications9 total

Discovery of BIIB068: A Selective, Potent, Reversible Bruton’s Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases
Journal of Medicinal Chemistry·2020· 36 citedOpen Access
Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction
Scientific Reports·2018· 26 citedOpen Access
Synapto‐depressive effects of amyloid beta require <scp>PICK</scp>1
European Journal of Neuroscience·2014· 64 citedOpen Access
ChemInform Abstract: Polymer‐Supported Copper(I) Catalysts for the Experimentally Simplified Azide—Alkyne Cycloaddition.
ChemInform·2008
Polymer‐Supported Copper(I) Catalysts for the Experimentally Simplified Azide–Alkyne Cycloaddition
QSAR & Combinatorial Science·2007· 93 cited
Polytriazoles as Copper(I)‐Stabilizing Ligands in Catalysis.
ChemInform·2004· 6 citedOpen Access
Polytriazoles as Copper(I)-Stabilizing Ligands in Catalysis
Organic Letters·2004· 1.5k cited
Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition
Journal of the American Chemical Society·2003· 1.6k cited
A Mild and General Solid-Phase Method for the Synthesis of Chiral Polyamines. Solution Studies on the Cleavage of Borane−Amine Intermediates from the Reduction of Secondary Amides
The Journal of Organic Chemistry·2001· 55 cited

Frequent Co-authors

Valery V. Fokin(5), Robert Hilgraf(3), K. Barry Sharpless(3), Charles C. Banos(2), Edward Yin-Shiang Lin(2), G. Kumaravel(2), Robert H. Scannevin(2), Kenneth J. Rhodes(2), Richard L. Huganir(2), Kevin M. Guckian(2), Anthone W. Dunah(2), D.J. Marcotte(2), Qian Wang(1), M. G. Finn(1), Stephanie Alfonso(1), Helmut W. Kessels(1), Roberto Malinow(1), Sukhdev Manku(1), Carmen Laplante(1), D Kopac(1)