Ajay S. Thatte

California University of Pennsylvania — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

19h-index1.3kcitations33works19.32yr avg
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Research Topics

RNA Interference and Gene Delivery(15), Immunotherapy and Immune Responses(8), CAR-T cell therapy research(8), Lipid Membrane Structure and Behavior(5), Cellular transport and secretion(5)

Publications33 total

Anti-CD38-Targeted Piperazine-Derived Lipid Nanoparticles Overcome Hepatic Clearance for mRNA Delivery to Multiple Myeloma Cells <i>In Vivo</i>
2025Open Access
Lipid nanoparticles for engineering next generation CAR T cell immunotherapy
Nanoscale Horizons·2025· 2 citedOpen Access
Author response for "Lipid nanoparticles for engineering next generation CAR T cell immunotherapy"
2025
Circular RNA lipid nanoparticle vaccine against SARS-CoV-2
Proceedings of the National Academy of Sciences·2025· 4 citedOpen Access
Bioinspired Oxidized mRNA Lipid Nanoparticles for <i>Ex Vivo</i> Engineering of Chimeric Antigen Receptor Macrophages Targeting Solid Tumors
2025Open Access
High-throughput <i>in vivo</i> screening using barcoded mRNA identifies lipid nanoparticles with extrahepatic tropism for cancer immunotherapy
2025· 1 citedOpen Access
Probing the Role of Lipid Nanoparticle Elasticity on mRNA Delivery to the Placenta
Nano Letters·2025· 7 cited
Publisher Correction: Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia
Nature·2025· 3 citedOpen Access
Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia
Nature·2024· 79 citedOpen Access
Fine-tuning extracellular fluid viscosity enhances gene delivery
Nature Chemical Engineering·2024
In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells
Proceedings of the National Academy of Sciences·2024· 31 citedOpen Access
Drug delivery technologies for autoimmunity therapies
Advanced Drug Delivery Reviews·2024
High-Throughput <i>In Vivo</i> Screening Identifies Differential Influences on mRNA Lipid Nanoparticle Immune Cell Delivery by Administration Route
ACS Nano·2024· 38 cited
EGFR-targeted ionizable lipid nanoparticles enhance in vivo mRNA delivery to the placenta
Journal of Controlled Release·2024· 49 citedOpen Access
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy (Adv. Mater. 26/2024)
Advanced Materials·2024Open Access
Oxidized mRNA Lipid Nanoparticles for In Situ Chimeric Antigen Receptor Monocyte Engineering
Advanced Functional Materials·2024· 40 citedOpen Access
Ionizable Lipid Nanoparticle-Mediated TRAIL mRNA Delivery in the Tumor Microenvironment to Inhibit Colon Cancer Progression
International Journal of Nanomedicine·2024· 27 citedOpen Access
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy
Advanced Materials·2024· 63 citedOpen Access
Emerging strategies for nanomedicine in autoimmunity
Advanced Drug Delivery Reviews·2024· 22 citedOpen Access
Responsive biomaterials: optimizing control of cancer immunotherapy
Nature Reviews Materials·2023· 154 cited
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Frequent Co-authors

Michael J. Mitchell(26), Alex G. Hamilton(17), Hannah C. Safford(13), Drew Weissman(13), Margaret M. Billingsley(11), Alvin J. Mukalel(11), Kelsey L. Swingle(11), Xuexiang Han(11), Mohamad‐Gabriel Alameh(10), Hannah C. Geisler(10), Ann E. Metzloff(7), Marshall S. Padilla(7), Ryann A. Joseph(6), Wade F. Zeno(6), Jeanne C. Stachowiak(6), Ningqiang Gong(5), Lulu Xue(5), Eileen M. Lafer(5), Rakan El‐Mayta(4), David Mai(4)