Patrick Depreux

Université de Lille — France

Chemistry · Physical Sciences

23h-index1.9kcitations130works1.02yr avg
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Research Topics

Synthesis and Biological Evaluation(26), Synthesis and Reactions of Organic Compounds(19), Quinazolinone synthesis and applications(18), Phenothiazines and Benzothiazines Synthesis and Activities(16), Synthesis of heterocyclic compounds(15)

Publications130 total

Design, synthesis and evaluation of pyrimidinobenzylamide and pyrimidinothiophenamide derivatives as inhibitors of DOT1L and related epigenetic targets DNMT3a, PRMT4 and other HMTs
RSC Medicinal Chemistry·2025· 1 citedOpen Access
Study of the Effect of Substituents of ortho-Phenylenediamines in the Opening of Lactones and Lactams for Access to Benzimidazol-2-yl Alkanols and Benzimidazol-2-yl Alkylamines
Synlett·2020· 6 citedOpen Access
Regioselective and efficient halogenation of 4,5-unsubstituted alkyl 3-hydroxypyrrole/3-hydroxythiophene-2-yl-carboxylates
Tetrahedron Letters·2017· 4 cited
Chiral separation of new sulfonamide derivatives and evaluation of their enantioselective affinity for human carbonic anhydrase II by microscale thermophoresis and surface plasmon resonance
Journal of Pharmaceutical and Biomedical Analysis·2017· 21 cited
DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge
Biomolecules·2017· 157 citedOpen Access
Amine coupling versus biotin capture for the assessment of sulfonamide as ligands of hCA isoforms
Analytical Biochemistry·2016· 1 cited
Synthesis and biological evaluation of di-aryl urea derivatives as c-Kit inhibitors
Bioorganic & Medicinal Chemistry·2015· 18 citedOpen Access
Quinazoline derivatives as anticancer drugs: a patent review (2011 – present)
Expert Opinion on Therapeutic Patents·2015· 135 cited
Inhibition of tumor cell growth and angiogenesis by 7-Aminoalkoxy-4-aryloxy-quinazoline ureas, a novel series of multi-tyrosine kinase inhibitors
European Journal of Medicinal Chemistry·2014· 34 cited
Label-free characterization of carbonic anhydrase-novel inhibitor interactions using surface plasmon resonance, isothermal titration calorimetry and fluorescence-based thermal shift assays
Journal of Molecular Recognition·2013· 24 cited
New selective carbonic anhydrase IX inhibitors: Synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides
Bioorganic & Medicinal Chemistry·2012· 62 citedOpen Access
Synthesis and Structure–Activity Relationships of (Aryloxy)quinazoline Ureas as Novel, Potent, and Selective Vascular Endothelial Growth Factor Receptor-2 Inhibitors
Journal of Medicinal Chemistry·2012· 62 citedOpen Access
CCDC 752326: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
CCDC 752325: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
CCDC 752842: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
ChemInform Abstract: Novel and Efficient One‐Pot Synthesis of (Aminophenyl)carbamic Acid Esters.
ChemInform·2011
Novel and Efficient One-Pot Synthesis of (Aminophenyl)carbamic Acid Esters
Synthetic Communications·2011· 5 cited
Preparative enantiomeric separation of new selective CB<sub>2</sub>receptor agonists by liquid chromatography on polysaccharide‐based chiral stationary phases: Determination of enantiomeric purity and assignment of absolute stereochemistry by X‐ray structure analysis
Chirality·2011· 5 cited
Impact of aryloxy-linked quinazolines: A novel series of selective VEGFR-2 receptor tyrosine kinase inhibitors
Bioorganic & Medicinal Chemistry Letters·2011· 75 citedOpen Access
[4-(6,7-Disubstituted quinazolin-4-ylamino)phenyl] carbamic acid esters: a novel series of dual EGFR/VEGFR-2 tyrosine kinase inhibitors
MedChemComm·2010· 62 cited
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Frequent Co-authors

Laurence Goossens(15), Daniel Lesieur(11), Jean‐Pierre Hénichart(11), Perrine Six(8), Séverine Ravez(7), Jean‐François Goossens(7), Jacques H. Poupaert(7), Murielle Mimeault(6), Amaury Farce(6), Antonio Garofalo(6), Amélie Lemoine(6), Surinder K. Batra(5), Ousmane Diouf(5), Éric Fourmaintraux(5), Pierre Renard(4), Bruno Pfeiffer(4), Ming‐Fong Lin(4), Eric Stern(4), Régis Millet(4), Catherine Foulon(4)