Adam K. Charnley

Chemistry · Physical Sciences

16h-index1.7kcitations31works0.02yr avg
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Research Topics

Synthesis and biological activity(6), interferon and immune responses(6), Spectroscopy and Quantum Chemical Studies(5), Computational Drug Discovery Methods(4), Chemical Synthesis and Analysis(4)

Publications31 total

To Market, to Market—2019: Small Molecules
Medicinal chemistry reviews·2020· 4 cited
Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel
ACS Medicinal Chemistry Letters·2020· 4 citedOpen Access
Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors
ACS Medicinal Chemistry Letters·2019· 26 citedOpen Access
RIP2 Kinase Catalytic Domain complex with 5-Amino-1-Phenylpyrazole-4-Carboxamide.
2019
RIP2 Kinase Catalytic Domain complex with 5amino1tertbutyl3(3methoxyphenyl)1H pyrazole4carboxamide.
2019
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[<i>d</i>]thiazol-5-ylamino)-6-(<i>tert</i>-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases
Journal of Medicinal Chemistry·2019· 65 citedOpen Access
Author Correction: Design of amidobenzimidazole STING receptor agonists with systemic activity
Nature·2019· 43 citedOpen Access
Design of amidobenzimidazole STING receptor agonists with systemic activity
Nature·2018· 806 cited
Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel
ACS Medicinal Chemistry Letters·2018· 35 citedOpen Access
The Identification and Pharmacological Characterization of 6-( <i>tert</i> -Butylsulfonyl)- <i>N</i> -(5-fluoro-1 <i>H</i> -indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase
Journal of Medicinal Chemistry·2016· 122 citedOpen Access
CCDC 1474873: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity
Bioorganic & Medicinal Chemistry·2015· 34 citedOpen Access
RIP2 Kinase Catalytic Domain (1 - 310) complex with Benzimidazole
2015
RIP2 Kinase Catalytic Domain (1 - 310) complex with Biaryl Urea
2015
RIP2 Kinase Catalytic Domain (1 - 310) complex with Biphenylsulfonamide
2015
RIP2 Kinase Catalytic Domain (1 - 310) complex with AMP-PCP
2015
RIP2 Kinase Catalytic Domain (1 - 310)
2015
CCDC 269171: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
Pyrrolinone-Based Peptidomimetics.“<i>Let the Enzyme or Receptor be the Judge</i>”
Accounts of Chemical Research·2010· 92 citedOpen Access
Design, Synthesis, and Structural Analysis of <scp>d</scp>,<scp>l</scp>-Mixed Polypyrrolinones. 1. From Nonpeptide Peptidomimetics to Nanotubes
Organic Letters·2010· 8 cited
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Frequent Co-authors

Peter J. Gough(14), Robert W. Marquis(14), John Bertin(14), M.A. Convery(14), Linda Casillas(12), Amos B. Smith(11), John F. Mehlmann(8), Michael Reilly(7), Bartholomew J. Votta(7), Michael T. Ouellette(7), Ralph Hirschmann(7), Robert R. Singhaus(6), Joseph J. Romano(6), Pamela A. Haile(6), David B. Lipshutz(6), Robin M. Hochstrasser(5), Michael J. Bury(5), Ami S. Lakdawala(5), Biva M. Desai(5), Carol A. Capriotti(5)