David B. Lipshutz

Immunology and Microbiology · Life Sciences

10h-index885citations16works0.02yr avg
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Research Topics

Immune Response and Inflammation(4), interferon and immune responses(4), Cytokine Signaling Pathways and Interactions(3), Bone health and treatments(2), Immune cells in cancer(2)

Publications16 total

Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel
ACS Medicinal Chemistry Letters·2020· 4 citedOpen Access
Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors
ACS Medicinal Chemistry Letters·2019· 26 citedOpen Access
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[<i>d</i>]thiazol-5-ylamino)-6-(<i>tert</i>-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases
Journal of Medicinal Chemistry·2019· 65 citedOpen Access
Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel
ACS Medicinal Chemistry Letters·2018· 35 citedOpen Access
The Identification and Pharmacological Characterization of 6-( <i>tert</i> -Butylsulfonyl)- <i>N</i> -(5-fluoro-1 <i>H</i> -indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase
Journal of Medicinal Chemistry·2016· 122 citedOpen Access
CCDC 1474873: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Identification and characterization of potent, selective small molecule RIP2 kinase inhibitors (INM6P.422)
The Journal of Immunology·2014
Tu1921 Selective Inhibitors of RIP2 Kinase Activity Reduce PRO-Inflammatory Cytokine Production in IBD Mucosal Biopsy Cultures and Inflammation in Murine TNBS-Induced Colitis
Gastroenterology·2012
Identification of Blau Syndrome disease signatures
Pediatric Rheumatology·2011· 3 citedOpen Access
Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes
Arthritis & Rheumatism·2009· 300 citedOpen Access
Identification and Cloning of a Connective Tissue Growth Factor-like cDNA from Human Osteoblasts Encoding a Novel Regulator of Osteoblast Functions
Journal of Biological Chemistry·1999· 99 citedOpen Access
A Novel Human Bone Marrow Stroma-Derived Cell Line TF274 Is Highly Osteogenic In Vitro and In Vivo
Calcified Tissue International·1998· 23 cited
Identification and characterization of endothelin receptors on rat osteoblastic osteosarcoma cells: down-regulation by 1,25-dihydroxy-vitamin D3.
Molecular Pharmacology·1995· 32 cited
Characterization of cAMP-dependent inhibition of LPS-induced TNFα production by rolipram, a specific phosphodiesterase IV (PDE IV) inhibitor
International Journal of Immunopharmacology·1994· 137 cited
Protein kinase C regulates TNF-alpha production by human monocytes.
PubMed·1993· 29 cited
Inhibition of CD44, CD45 and LFA-3 mediated cytokine release from human monocytes by SK&amp;F 86002 and pentoxifylline
International Journal of Immunopharmacology·1993· 10 cited

Frequent Co-authors

John Bertin(9), Bartholomew J. Votta(8), Pamela A. Haile(8), Peter J. Gough(8), Robert W. Marquis(7), Biva M. Desai(7), Carol A. Capriotti(7), Michael Reilly(7), Linda Casillas(7), John F. Mehlmann(6), Adam K. Charnley(6), M.A. Convery(6), Scott B. Berger(6), Helen H. Sun(6), Rakesh Nagilla(6), Michael T. Ouellette(6), Uma Prabhakar(5), Michael J. Bury(5), Ami S. Lakdawala(5), Barbara A. Swift(5)