Brian A. Otter

Albert Einstein College of Medicine — United States

Chemistry · Physical Sciences

21h-index1.1kcitations82works0.02yr avg
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Research Topics

Synthesis and Characterization of Heterocyclic Compounds(30), DNA and Nucleic Acid Chemistry(20), Biochemical and Molecular Research(19), Synthesis and Biological Evaluation(15), HIV/AIDS drug development and treatment(14)

Publications82 total

ChemInform Abstract: Studies on the Synthesis of S<sup>5′</sup>,6‐Methano‐5′‐thiouridines.
ChemInform·1998
Studies on the Synthesis of<i>S</i><sup>5′</sup>,6-Methano-5′-Thiourldines
Nucleosides and Nucleotides·1997· 1 cited
Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii
Biochemical Pharmacology·1996· 33 cited
Conformational Properties of Purine-Like <i>C</i>-Nucleosides
Nucleosides and Nucleotides·1996· 5 cited
ChemInform Abstract: Synthesis of Quinazoline C‐Nucleosides: A New Class of 6:6 Bicyclic Purine‐Like Analogues.
ChemInform·1995
5-Ethoxy-2'-deoxyuridine, a novel substrate for thymidine phosphorylase, potentiates the antitumor activity of 5-fluorouracil when used in combination with interferon, an inducer of thymidine phosphorylase expression.
PubMed·1995· 40 cited
A Convenient Synthesis of D-Psicofuranosyl Nucleosides1
Nucleosides Nucleotides & Nucleic Acids·1995· 11 cited
Synthesis of Quinazoline C-Nucleosides: A New Class of 6:6 Bicyclic Purine-Like Analogues.1
Nucleosides Nucleotides & Nucleic Acids·1995· 11 cited
ChemInform Abstract: Synthesis of Pyrrolo(2,1‐f) (1,2,4)triazine Congeners of Nucleic Acid Purines via the N‐Amination of 2‐Substituted Pyrroles.
ChemInform·1995
ChemInform Abstract: Nucleophilic Substitution Reactions of 5‐Bromo‐6‐methyluridines.
ChemInform·1995
ChemInform Abstract: 4‐Aza‐7,9‐dideazaadenosine, a New Cytotoxic Synthetic C‐Nucleoside Analogue of Adenosine.
ChemInform·1994
O<sup>5′,6</sup>-Methanocytidine — Synthesis, Conformational Properties and Deamination by Cytidine Deaminase
Nucleosides and Nucleotides·1994· 8 cited
Guanylhydrazones in therapy of Pneumocystis carinii pneumonia in immunosuppressed rats
Antimicrobial Agents and Chemotherapy·1994· 12 citedOpen Access
ChemInform Abstract: Synthesis and in vitro Cytotoxicity of 6‐Vinyluridine and Related Compounds.
ChemInform·1994
Synthesis of pyrrolo[2,1‐<i>f</i>][1,2,4]triazine congeners of nucleic acid purines <i>via</i> the <i>N</i>‐amination of 2‐substituted pyrroles
Journal of Heterocyclic Chemistry·1994· 28 cited
4-aza-7,9-dideazaadenosine, a new cytotoxic synthetic C-nucleoside analogue of adenosine
Tetrahedron Letters·1994· 53 cited
Potentiation of the antitumor activity of 5-fluorouracil in colon carcinoma cells by the combination of interferon and deoxyribonucleosides results from complementary effects on thymidine phosphorylase.
PubMed·1994· 52 cited
Nucleophilic Substitution Reactions of 5-Bromo-6-methyluridines
Nucleosides and Nucleotides·1994· 3 cited
Synthesis and in vitro cytotoxicity of 6-vinyluridine and related compounds
Bioorganic & Medicinal Chemistry Letters·1994· 10 cited
ChemInform Abstract: Synthesis of Some New Thieno(3,4‐d)pyrimidines and Their C‐Nucleosides.
ChemInform·1993
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Frequent Co-authors

Robert S. Klein(21), Jack J. Fox(13), Elvira A. Falco(8), Shirish A. Patil(6), R. Paul Gagnier(4), Isaac M. Sasson(4), Tohru Ueda(3), Mahmoud H. el Kouni(3), Fardos N.M. Naguib(3), L. Hough(3), Sreenivasulu Megati(3), Mu Ill Lim(2), Wu Yun Ren(2), Peter D. Walzer(2), J Foy(2), Paul E. Steele(2), Michael White(2), Edward L. Schwartz(2), Nicole Baptiste(2), Scott Wadler(2)