Lara Álvarez

Instituto de Salud Carlos III — Spain

Biochemistry, Genetics and Molecular Biology · Life Sciences

7h-index491citations14works0.02yr avg
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Research Topics

CRISPR and Genetic Engineering(12), DNA Repair Mechanisms(8), Pluripotent Stem Cells Research(4), Virus-based gene therapy research(3), RNA Interference and Gene Delivery(3)

Publications14 total

NHEJ-Mediated Gene Editing, a Versatile Approach to Correct a Variety of Fanconi Anemia Genes in HSCs
Blood·2019
NHEJ-Mediated Repair of CRISPR-Cas9-Induced DNA Breaks Efficiently Corrects Mutations in HSPCs from Patients with Fanconi Anemia
Cell stem cell·2019· 85 citedOpen Access
Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia
Nature Medicine·2019· 171 cited
Advances in the Gene Therapy of Patients with Fanconi Anemia
Blood·2018· 3 cited
NHEJ-Mediated Gene Editing: An Efficient Approach to Correct Mutations in Hematopoietic Stem and Progenitor Cells from Patients with Fanconi Anemia
SSRN Electronic Journal·2018Open Access
Therapeutic gene editing in <scp>CD</scp> 34 <sup>+</sup> hematopoietic progenitors from Fanconi anemia patients
EMBO Molecular Medicine·2017· 58 citedOpen Access
558. Targeted Gene Therapy in CD34+ Cells from Healthy Donors and Fanconi Anemia Patients
Molecular Therapy·2016Open Access
<scp>BCR–JAK2</scp> drives a myeloproliferative neoplasm in transplanted mice
The Journal of Pathology·2015· 3 cited
Targeted gene therapy and cell reprogramming in <scp>F</scp> anconi anemia
EMBO Molecular Medicine·2014· 70 citedOpen Access
Down-regulated expression of hsa-miR-181c in Fanconi anemia patients: implications in TNFα regulation and proliferation of hematopoietic progenitor cells
Blood·2012· 26 cited
Development of Lentiviral Vectors with Optimized Transcriptional Activity for the Gene Therapy of Patients with Fanconi Anemia
Human Gene Therapy·2009· 49 cited
In vivo proliferation advantage of genetically corrected hematopoietic stem cells in a mouse model of Fanconi anemia FA-D1
Blood·2008· 26 citedOpen Access
Optimization of lentiviral vectors for the gene therapy of fanconi anemia
Blood Cells Molecules and Diseases·2008
Comprehensive pharmacogenetic and epigenetic analysis, and its predictive value for 5FU/oxaliplatin chemotherapy response
Clinical Cancer Research·2007

Frequent Co-authors

Juan A. Bueren(13), Paula Rı́o(12), Francisco J Roman‐Rodriguez(7), Jordi Surrallés(7), Begoña Díez(7), Julián Sevilla(6), Susana Navarro(5), José C. Segovia(5), Massimo Bogliolo(4), Guillermo Güenechea(4), Laura Ugalde(4), Helmut Hanenberg(4), Sandra Rodríguez(4), Elena Almarza(4), José Antonio Casado(3), M. Luz Lozano(3), Cristina Díaz de Heredia(3), Marı́a José Ramı́rez(3), Raúl Torres(3), Rocío Baños(3)