Diego Avellaneda Matteo

San Diego State University — United States

Medicine · Health Sciences

4h-index90citations12works1.32yr avg
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Research Topics

Glioma Diagnosis and Treatment(9), Cancer, Hypoxia, and Metabolism(7), Epigenetics and DNA Methylation(5), Cancer Genomics and Diagnostics(5), Enzyme Structure and Function(3)

Publications12 total

Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms
Nature Communications·2024· 3 citedOpen Access
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms
Research Square (Research Square)·2024Open Access
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms
2024· 1 citedOpen Access
Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen–Deuterium Exchange Mass Spectrometry
Biochemistry·2023· 6 citedOpen Access
The Catalytic Features of IDH1 Mutations Can Drive Neomorphic Activity, Phenotype Severity, and Inhibitor Binding
The FASEB Journal·2020
The effect of acetylation on isocitrate dehydrogenase 1 regulation
The FASEB Journal·2020· 1 cited
Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity
Biochemistry·2019· 6 citedOpen Access
Molecular Mechanisms of Isocitrate Dehydrogenase 1 Mutants in Driving the Oncogenic Neomorphic Reaction
The FASEB Journal·2019
Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants
Biochemical Journal·2018· 15 cited
Understanding the Structure‐Function Relationship of IDH1 R132 mutants and the Effect of Allosteric Inhibitors
The FASEB Journal·2018
Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency
Journal of Biological Chemistry·2017· 58 citedOpen Access
Enzymes Running in Reverse: Catalytic Studies on Isocitrate Dehydrogenase Mutations Implicated in Cancer
The FASEB Journal·2016

Frequent Co-authors

Christal D. Sohl(12), Jamie M. Schiffer(7), Adam Grunseth(4), Lucas A. Luna(4), Elene Albekioni(4), Nalani J. Coleman(4), Elizabeth A. Komives(4), Steve Silletti(4), Andrey A. Bobkov(4), David A. Scott(3), An Hoang(3), Grace A. Wells(3), Kaitlyn A. Sabo(3), Giovanni Quichocho(3), Matthew Mealka(3), Nicole A. Sierra(3), Rachel Khoury(3), Timothy Mai(3), Andrew L. Cooksy(3), Tom Huxford(3)