Manolis Kellis

Broad Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

138h-index124.9kcitations1.1kworks15.92yr avg
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Research Topics

Genomics and Chromatin Dynamics(116), RNA and protein synthesis mechanisms(79), RNA Research and Splicing(75), RNA modifications and cancer(73), Genomics and Phylogenetic Studies(72)

Publications1.1k total

Convergent Signals Encode Persistent Memory of Resilient States
2025· 1 cited
Energy Conservation Drives Adaptive Specialization Through Fine-tuned Organizations
2025· 1 citedOpen Access
Epigenetic control of metabolic identity across cell types
BMC Genomics·2025Open Access
Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease
Nature Aging·2025· 1 citedOpen Access
sc4D: spatio-temporal single-cell transcriptomics analysis through embedded optimal transport identifies joint glial response to Alzheimer’s disease pathology
2025
PRISM: ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores
2025Open Access
Multi-omics analysis of a pig-to-human decedent kidney xenotransplant
Nature·2025· 6 citedOpen Access
CONCERT predicts niche-aware perturbation responses in spatial transcriptomics
2025· 1 citedOpen Access
Melanoma to rhabdomyosarcoma plasticity in the setting of immunotherapy
2025Open Access
Integrating single-cell RNA-seq datasets with substantial batch effects
BMC Genomics·2025· 3 citedOpen Access
Programmed ribosomal frameshifting during <i>PLEKHM2</i> mRNA decoding generates a constitutively active proteoform that supports myocardial function
Science Advances·2025Open Access
Intraspecific sequence variation and complete genomes refine the identification of rapidly evolved regions in humans
2025· 1 citedOpen Access
Engineered 3D immuno-glial-neurovascular human miBrain model
Proceedings of the National Academy of Sciences·2025· 2 citedOpen Access
Type 2 Diabetes and Obesity Alter Exercise Training-Induced Transcriptional Adaptations to Subcutaneous White Adipose Tissue
2025Open Access
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer’s disease
Molecular Neurodegeneration·2025· 4 citedOpen Access
ABCA7 variants impact phosphatidylcholine and mitochondria in neurons
Nature·2025· 2 citedOpen Access
Translon: a single term for translated regions
Nature Methods·2025· 7 citedOpen Access
Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma
Nature Communications·2025· 6 citedOpen Access
Interpretable deep generative ensemble learning for single-cell omics with Hydra
2025Open Access
Disparities and trends in global representation of human genetics conferences: a 26-year longitudinal study of ASHG and ESHG
2025Open Access
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Frequent Co-authors

Roderic Guigó(11), Mark Gerstein(10), Eric S. Lander(9), Jason Ernst(8), B Bernstein(7), Pouya Kheradpour(7), Anshul Kundaje(7), Tim Hubbard(6), Tarjei S. Mikkelsen(6), Kevin P. White(6), Ayellet V. Segrè(5), Adam Frankish(5), Mark Diekhans(5), Michael F. Lin(5), Irwin Jungreis(5), Lucas D. Ward(5), J Stamatoyannopoulos(5), Alexander Stark(5), Bing Ren(5), Kristin Ardlie(4)