Megan D. Hoban

Forma Therapeutics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index1.6kcitations34works2.02yr avg
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Research Topics

CRISPR and Genetic Engineering(20), Virus-based gene therapy research(9), RNA Interference and Gene Delivery(7), CAR-T cell therapy research(7), Hemoglobinopathies and Related Disorders(5)

Publications34 total

In Vivo pan CAR therapy utilizing circular RNA for treatment of multiple myeloma
Blood·2025· 2 citedOpen Access
In Vivo pan CAR therapy utilizing circular RNA for treatment of autoimmune diseases
Blood·2025· 2 citedOpen Access
A single dose of a CD137 antibody–drug conjugate protects rhesus macaque allogeneic HCT recipients against acute GVHD
Blood·2025· 1 citedOpen Access
<i>In Vivo</i> panCAR-Mediated Depletion of B Cells in Non-Human Primates Using a Circular (oRNA®) Anti-CD20 CAR
Blood·2024· 3 cited
CD117 Antibody-Drug Conjugate Conditioning Allows Efficient Engraftment of Gene-Modified CD34+ Cells with Fertility Preservation in a Rhesus Gene Therapy Model
Blood·2023· 1 cited
Fertility-preserving myeloablative conditioning using single-dose CD117 antibody-drug conjugate in a rhesus gene therapy model
Nature Communications·2023· 39 citedOpen Access
Ex Vivo Expansion with E478 Increases the Rate of CRISPR-Mediated Homology Directed Repair of the Beta-Globin Gene in Human Hematopoietic Stem Cells By &gt;10-Fold and Improves In Vivo Engraftment By &gt;120-Fold
Blood·2019· 1 cited
Editing the Sickle Cell Disease Mutation in Human Hematopoietic Stem Cells: Comparison of Endonucleases and Homologous Donor Templates
Molecular Therapy·2019· 122 citedOpen Access
Site-Specific Gene Editing of Human Hematopoietic Stem Cells for X-Linked Hyper-IgM Syndrome
Cell Reports·2018· 137 citedOpen Access
Phenotype Does not Always Equal Function: HDAC Inhibitors and UM171, but not SR1, Lead to Rapid Upregulation of CD90 on Non-Engrafting CD34+CD90-Negative Human Cells
Biology of Blood and Marrow Transplantation·2018· 1 citedOpen Access
A Non-Genotoxic Antibody Drug Conjugate Targeting C-Kit for Hematopoietic Stem Cell Transplant Conditioning
Biology of Blood and Marrow Transplantation·2018· 4 citedOpen Access
Mgta-456, Cord Blood CD34+ Cells Expanded with an Aryl Hydrocarbon Receptor Antagonist, Enhances Human Microglia Engraftment in the Brains of NSG Mice
Biology of Blood and Marrow Transplantation·2018Open Access
Aryl Hydrocarbon Receptor Antagonists Expand Adult Hematopoietic Stem Cells From Mobilized Peripheral Blood and Bone Marrow and Increase the Dose of CRISPR/Cas9 Gene-Edited NSG-Repopulating Cells
Biology of Blood and Marrow Transplantation·2018· 4 citedOpen Access
Comparison of hematopoietic stem cell expansion methods reveals that aryl hydrocarbon receptor inhibition optimally expands CD90 engrafting cells
SSRN Electronic Journal·2018Open Access
Phenotype Does Not Always Equal Function: HDAC Inhibitors and UM171, but Not SR1, Lead to Rapid Upregulation of CD90 on Non-Engrafting CD34+CD90-Negative Human Cells
Blood·2017· 1 cited
Characterization of Gene Alterations following Editing of the β-Globin Gene Locus in Hematopoietic Stem/Progenitor Cells
Molecular Therapy·2017· 29 citedOpen Access
CRISPR/Cas9-Mediated Correction of the Sickle Mutation in Human CD34+ cells
Molecular Therapy·2016· 214 citedOpen Access
Analyzing CRISPR genome-editing experiments with CRISPResso
Nature Biotechnology·2016· 482 citedOpen Access
118. Characterization of Chromosomal Alterations Using a Zinc-Finger Nuclease Targeting the Beta-Globin Gene Locus in Hematopoietic Stem/Progenitor Cells
Molecular Therapy·2016Open Access
A genome editing primer for the hematologist
Blood·2016· 30 citedOpen Access
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Frequent Co-authors

Donald B. Kohn(17), Roger P. Hollis(12), Zulema Romero(10), Caroline Y. Kuo(8), Sharon L. Hyzy(8), Alok V. Joglekar(7), Dianne Lumaquin(7), Aaron Cooper(7), Ana Katherine Gonçalves(7), Anthony E. Boitano(7), Michael L. Kaufman(6), Joseph Long(6), Jennifer Proctor(6), Michelle Ho(5), Fabrizia Urbinati(5), Michael C. Holmes(5), Beatriz Campo-Fernández(5), Hillary L. Adams(5), Daniel E. Bauer(4), Gregory J. Cost(4)