Raymond C. Trievel

Philadelphia College of Osteopathic Medicine — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

42h-index7.7kcitations115works0.02yr avg
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Research Topics

Epigenetics and DNA Methylation(61), Cancer-related gene regulation(56), RNA modifications and cancer(34), Genomics and Chromatin Dynamics(18), Enzyme Structure and Function(12)

Publications115 total

Abstract 1518 A Binding Interaction Analysis of UHRF2 Mutants
Journal of Biological Chemistry·2025Open Access
Abstract 1735 Structure & Substrate Specificity of Legionella pneumophila Histone Lysine Methyltransferases
Journal of Biological Chemistry·2025Open Access
An optimized purification protocol for enzymatically synthesized S-adenosyl-L-methionine (SAM) for applications in solution state infrared spectroscopic studies
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy·2024
Intrinsic catalytic properties of histone H3 lysine-9 methyltransferases preserve monomethylation levels under low S-adenosylmethionine
Journal of Biological Chemistry·2023· 9 citedOpen Access
An Optimized Purification Protocol for Enzymatically Synthesized S-Adenosyl-L-Methionine (Sam) for Applications in Solution State Infrared Spectroscopic Studies
SSRN Electronic Journal·2023Open Access
Intrinsic catalytic properties of histone H3 lysine-9 methyltransferases preserve monomethylation levels under low <i>S-</i> adenosylmethionine
2022· 2 citedOpen Access
EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression
iScience·2022· 15 citedOpen Access
Detection of cofactor conformer exchange in the active sites of methyltransferases with vibrational spectroscopy
The FASEB Journal·2022
Investigating the structure of UHRF2 TTD‐PHD with H3K9me3
The FASEB Journal·2022
Molecular investigation of the tandem Tudor domain and plant homeodomain histone binding domains of the epigenetic regulator <scp>UHRF2</scp>
Proteins Structure Function and Bioinformatics·2021· 7 citedOpen Access
Differential processing and localization of human Nocturnin controls metabolism of mRNA and nicotinamide adenine dinucleotide cofactors
Journal of Biological Chemistry·2020· 15 citedOpen Access
An H3K9 methylation-dependent protein interaction regulates the non-enzymatic functions of a putative histone demethylase
eLife·2020· 32 citedOpen Access
Author response: An H3K9 methylation-dependent protein interaction regulates the non-enzymatic functions of a putative histone demethylase
2020· 1 citedOpen Access
Differential processing and localization of human Nocturnin controls metabolism of mRNA and nicotinamide dinucleotide metabolites
2020· 1 citedOpen Access
A non‐enzymatic function associated with a putative histone demethylase regulates heterochromatin spreading and inheritance
The FASEB Journal·2019
Structural and Functional Characterization of Sulfonium Carbon–Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1
Biochemistry·2019· 4 cited
A non-enzymatic function associated with a putative histone demethylase licenses epigenetic inheritance
2019Open Access
Crystallographic and Computational Characterization of Methyl Tetrel Bonding in S-Adenosylmethionine-Dependent Methyltransferases
Molecules·2018· 40 citedOpen Access
Reply to ‘Misreading chaperone–substrate complexes from random noise’
Nature Structural & Molecular Biology·2018· 2 cited
The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells
Nucleic Acids Research·2018· 30 citedOpen Access
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Frequent Co-authors

Jean‐François Couture(11), Robert L. Houtz(10), Scott Horowitz(8), Ronen Marmorstein(7), Lynnette M.A. Dirk(7), P.A. Del Rizzo(6), Shelley L. Berger(5), Evys Collazo(5), C. David Allis(4), J.S. Brunzelle(4), Steve Scheiner(4), Jeannie R. Rojas(3), Ali Shilatifard(3), Stacie L. Bulfer(3), Roberta Magnani(3), Joseph D. Yesselman(3), Hashim M. Al‐Hashimi(3), Swathi Krishnan(3), Zhou Jian-xin(2), James H. Hurley(2)