Bo Wang

Pennsylvania State University — United States

Energy · Physical Sciences

19h-index1.8kcitations35works4.72yr avg
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Research Topics

Metalloenzymes and iron-sulfur proteins(11), Catalytic C–H Functionalization Methods(6), RNA modifications and cancer(6), Carbohydrate Chemistry and Synthesis(4), Metal-Catalyzed Oxygenation Mechanisms(4)

Publications35 total

Structural Basis for Iterative Methylation by a Cobalamin-dependent Radical S-Adenosylmethionine Enzyme in Cystobactamids Biosynthesis
2025Open Access
Radical Fluoromethylation Enabled by Cobalamin-Dependent Radical SAM Enzymes
ACS Bio & Med Chem Au·2025· 5 citedOpen Access
Structural Evidence for DUF512 as a Radical <i>S</i>-Adenosylmethionine Cobalamin-Binding Domain
ACS Bio & Med Chem Au·2024· 9 citedOpen Access
Enzymatic Fluoromethylation Enabled by the <i>S</i>-Adenosylmethionine Analog <i>Te</i>-Adenosyl-<i>L</i>-(fluoromethyl)homotellurocysteine
ACS Central Science·2023· 28 citedOpen Access
Supplementary Tables 1 - 2 from miR-148b Functions as a Tumor Suppressor in Pancreatic Cancer by Targeting AMPKα1
2023Open Access
A miR-34a-guided, tRNAiMet-derived, piR_019752-like fragment (tRiMetF31) suppresses migration and angiogenesis of breast cancer cells via targeting PFKFB3
Cell Death Discovery·2022· 19 citedOpen Access
Discovery, structure and mechanism of a tetraether lipid synthase
Nature·2022· 73 citedOpen Access
Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB
Nature·2021· 47 citedOpen Access
Structural basis for non-radical catalysis by TsrM, a radical SAM methylase
Nature Chemical Biology·2021· 62 citedOpen Access
MEX3A is upregulated in esophageal squamous cell carcinoma (ESCC) and promotes development and progression of ESCC through targeting CDK6
Aging·2020· 20 citedOpen Access
Radical S-Adenosylmethionine Methylases
Elsevier eBooks·2020· 4 cited
Steric Enforcement of <i>cis</i>-Epoxide Formation in the Radical C–O-Coupling Reaction by Which (<i>S</i>)-2-Hydroxypropylphosphonate Epoxidase (HppE) Produces Fosfomycin
Journal of the American Chemical Society·2019· 16 cited
Function, timing and catalytic mechanism of NosN, a class C radical SAM methylase involved in the biosynthesis of nosiheptide's side‐ring system
The FASEB Journal·2019
Synthesis of reversible PAD4 inhibitors via copper-catalyzed C−H arylation of benzimidazole
Science China Chemistry·2019· 8 cited
DeepGeneMD: A Joint Deep Learning Model for Extracting Gene Mutation-Disease Knowledge from PubMed Literature
2019· 4 citedOpen Access
Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives
Chinese Chemical Letters·2018· 14 cited
Stereochemical and Mechanistic Investigation of the Reaction Catalyzed by Fom3 from <i>Streptomyces fradiae</i>, a Cobalamin-Dependent Radical <i>S</i>-Adenosylmethionine Methylase
Biochemistry·2018· 40 citedOpen Access
Two Distinct Mechanisms for C–C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance
Journal of the American Chemical Society·2018· 132 citedOpen Access
Enhanced Solubilization of Class B Radical <i>S</i>-Adenosylmethionine Methylases by Improved Cobalamin Uptake in <i>Escherichia coli</i>
Biochemistry·2018· 89 citedOpen Access
NosN, a Radical <i>S</i>-Adenosylmethionine Methylase, Catalyzes Both C1 Transfer and Formation of the Ester Linkage of the Side-Ring System during the Biosynthesis of Nosiheptide
Journal of the American Chemical Society·2017· 57 citedOpen Access
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Frequent Co-authors

Squire J. Booker(14), Gong Chen(8), Gang He(7), Anthony J. Blaszczyk(6), William A. Nack(5), Shu‐Yu Zhang(4), Carsten Krebs(4), Amie K. Boal(4), Hayley Knox(4), Alexey Silakov(3), David F. Iwig(3), Tyler L. Grove(3), Jinhe Cui(3), Noah P. Dunham(2), Wei‐chen Chang(2), Andrew J. Mitchell(2), Jonathan A. Bergman(2), J. Martin Bollinger(2), Chengxi Lu(2), Jungang Zhang(2)