Paolo Mascagni

Italfarmaco (Italy) — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

43h-index6.7kcitations159works0.02yr avg
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Research Topics

Histone Deacetylase Inhibitors Research(39), Chemical Synthesis and Analysis(29), Protein Structure and Dynamics(25), Heat shock proteins research(19), Analytical Chemistry and Chromatography(13)

Publications159 total

Correction to: Histone deacetylase inhibitor ITF2357 (givinostat) reverts transformed phenotype and counteracts stemness in in vitro and in vivo models of human glioblastoma
Journal of Cancer Research and Clinical Oncology·2019· 2 citedOpen Access
Histone deacetylase inhibitor ITF2357 (givinostat) reverts transformed phenotype and counteracts stemness in in vitro and in vivo models of human glioblastoma
Journal of Cancer Research and Clinical Oncology·2018· 35 citedOpen Access
Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation
Arthritis Research & Therapy·2018· 27 citedOpen Access
Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism
Science Translational Medicine·2018· 149 citedOpen Access
Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes
Annals of the Rheumatic Diseases·2016· 150 citedOpen Access
Specific Inhibition of Histone Deacetylase 8 Reduces Gene Expression and Production of Proinflammatory Cytokines in Vitro and in Vivo
Journal of Biological Chemistry·2014· 62 citedOpen Access
Histone Deacetylase Inhibitors Modulate Interleukin 6-dependent CD4+ T Cell Polarization in Vitro and in Vivo
Journal of Biological Chemistry·2014· 86 citedOpen Access
Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection
Proceedings of the National Academy of Sciences·2014· 70 citedOpen Access
Tu1646 HDAC Dependent Regulation of the IL-6/STAT3 Pathway During T Helper Cells Activation
Gastroenterology·2013Open Access
P055 HDAC dependent regulation of the IL-6/STAT3 pathway during T helper cell activation
Journal of Crohn s and Colitis·2013Open Access
Preclinical Studies in the mdx Mouse Model of Duchenne Muscular Dystrophy with the Histone Deacetylase Inhibitor Givinostat
Molecular Medicine·2013· 149 citedOpen Access
The lysine deacetylase inhibitor givinostat inhibits β-cell IL-1β induced IL-1β transcription and processing
Islets·2012· 15 citedOpen Access
Givinostat and hydroxyurea synergize in vitro to induce apoptosis of cells from JAK2V617F myeloproliferative neoplasm patients
Experimental Hematology·2012· 33 citedOpen Access
T.P.2 Givinostat improves histological and functional parameters in mdx mice dose and concentration dependently
Neuromuscular Disorders·2012
Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children
Diabetologia·2012· 92 cited
Functional consequences of inhibiting exocytosis of Weibel-Palade bodies in acute renal ischemia
American Journal of Physiology-Renal Physiology·2011· 14 citedOpen Access
Induction of M2 Macrophages via Inhibition of Histone Deacetylases
Gastroenterology·2011Open Access
Histone Deacetylase Inhibitors for Treating a Spectrum of Diseases Not Related to Cancer
Molecular Medicine·2011· 156 citedOpen Access
Pharmacokinetics, Safety and Inducible Cytokine Responses during a Phase 1 Trial of the Oral Histone Deacetylase Inhibitor ITF2357 (Givinostat)
Molecular Medicine·2011· 116 citedOpen Access
Inhibition of HDAC Activity by ITF2357 Ameliorates Joint Inflammation and Prevents Cartilage and Bone Destruction in Experimental Arthritis
Molecular Medicine·2011· 100 citedOpen Access
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Frequent Co-authors

Charles A. Dinarello(18), Gianluca Fossati(15), Flavio Leoni(10), Koichi Takayama(6), Pietro Pozzi(5), Britta Siegmund(5), N Qureshi(5), Thomas Mandrup‐Poulsen(5), Andrea Zaliani(4), Leonid L. Reznikov(4), William A. Gibbons(4), V. Monzani(4), Paolo Pagani(3), Giamila Fantuzzi(3), Daniela Modena(3), Rainer Glauben(3), Nils Billestrup(3), Josée Golay(3), Martino Introna(3), Alessandro Rambaldi(3)