Michael G. Dube

Neuroscience · Life Sciences

26h-index3.2kcitations39works0.02yr avg
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Research Topics

Regulation of Appetite and Obesity(28), Biochemical Analysis and Sensing Techniques(16), Neuropeptides and Animal Physiology(14), Adipose Tissue and Metabolism(10), Hypothalamic control of reproductive hormones(9)

Publications39 total

Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss
Journal of Endocrinology·2015· 14 citedOpen Access
Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay
Peptides·2009· 45 citedOpen Access
Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis
American Journal of Physiology-Heart and Circulatory Physiology·2008· 35 citedOpen Access
Abstract 1390: Enhanced Leptin Expression in the Hypothalamus Reverses p66ShcA Dependent Oxidative Stress and Myocyte Apoptosis in Akita Mice
Circulation·2008
Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice
Peptides·2008· 30 citedOpen Access
Low abundance of NPY in the hypothalamus can produce hyperphagia and obesity
Peptides·2007· 14 citedOpen Access
Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin
Neurobiology of Aging·2006· 36 cited
Hypothalamic clamp on insulin release by leptin-transgene expression
Peptides·2006· 36 cited
Central Leptin Gene Therapy Blocks Ovariectomy‐Induced Adiposity
Obesity·2006· 33 citedOpen Access
The hypothalamic paraventricular nucleus is not essential for orexigenic NPY or anorexigenic melanocortin action
Peptides·2006· 10 cited
Increased Leptin Expression in the Dorsal Vagal Complex Suppresses Adiposity without Affecting Energy Intake and Metabolic Hormones
Obesity·2006· 19 citedOpen Access
Central leptin differentially modulates ultradian secretory patterns of insulin, leptin and ghrelin independent of effects on food intake and body weight
Peptides·2005· 46 cited
High‐fat Diet‐induced Ultradian Leptin and Insulin Hypersecretion are Absent in Obesity‐resistant Rats*
Obesity Research·2005· 47 citedOpen Access
Perigestational suppression of weight gain with central leptin gene therapy results in lower weight F1 generation
Peptides·2005· 30 cited
Leptin Modulates Orexigenic Effects of Ghrelin and Attenuates Adiponectin and Insulin Levels and Selectively the Dark-Phase Feeding as Revealed by Central Leptin Gene Therapy
Endocrinology·2004· 92 citedOpen Access
Leptin Expression in Hypothalamic PVN Reverses Dietary Obesity and Hyperinsulinemia but Stimulates Ghrelin*
Obesity Research·2003· 64 cited
Decreased hypothalamic concentration of neuropeptide Y correlates with onset of hyperphagia in fa/fa rats on postnatal day 12
Physiology & Behavior·2003· 6 cited
Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity
Regulatory Peptides·2003· 179 cited
Long-Term Suppression of Weight Gain, Adiposity, and Serum Insulin by Central Leptin Gene Therapy in Prepubertal Rats: Effects on Serum Ghrelin and Appetite-Regulating Genes
Pediatric Research·2002· 64 cited
Central Leptin Gene Therapy Blocks High-Fat Diet-Induced Weight Gain, Hyperleptinemia, and Hyperinsulinemia
Diabetes·2002· 93 citedOpen Access
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Frequent Co-authors

Satya P. Kalra(35), Pushpa S. Kalra(31), Abhiram Sahu(6), Rita Torto(6), Stéphane Boghossian(4), Effiong E. Otukonyong(3), Naohiko Ueno(3), Shuye Pu(2), Bin Xu(2), Tamás L. Horváth(2), Michela Bagnasco(2), Elena Beretta(2), Urszula T. Iwaniec(2), Ashwani Malhotra(2), Himanshu Vashistha(2), Leonard G. Meggs(2), Christopher P. Phelps(2), Anne Lecklin(2), Wilse B. Webb(2), Alain Fournier(1)