S. Searle

St Bartholomew's Hospital — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

5h-index79citations7works0.02yr avg
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Research Topics

Virus-based gene therapy research(7), RNA Interference and Gene Delivery(3), Viral Infectious Diseases and Gene Expression in Insects(3), DNA Repair Mechanisms(1), Sarcoma Diagnosis and Treatment(1)

Publications7 total

Fusion of rous‐sarcoma‐virus‐transformed rat cells to morphologically normal human or rat cells results in transcriptional suppression of the provirus that depends on its chromosomal integration site
International Journal of Cancer·1990· 1 cited
Extinction of proviral expression in cell hybrids: Approaches to the isolation of a human suppressor gene
European Journal of Cancer and Clinical Oncology·1987
Transcription of Rous sarcoma proviruses in rat cells is determined by chromosomal position effects that fluctuate and can operate over long distances.
PubMed·1987· 17 cited
Expression of integrated Rous sarcoma viruses: DNA rearrangements 5′ to the provirus are common in transformed rat cells but not seen in infected but untransformed cells.
The EMBO Journal·1986· 14 citedOpen Access
Perturbed Hemopoiesis and the Generation Of Multipotential Stem Cell Clones in <i>src</i>-Infected Bone Marrow Cultures Is an Indirect or Transient Effect of the Oncogene
Molecular and Cellular Biology·1986· 5 cited
Perturbed hemopoiesis and the generation of multipotential stem cell clones in src-infected bone marrow cultures is an indirect or transient effect of the oncogene.
Molecular and Cellular Biology·1986· 19 citedOpen Access
The chromatin structure of Rous sarcoma proviruses is changed by factors that act in trans in cell hybrids.
The EMBO Journal·1985· 23 citedOpen Access

Frequent Co-authors

J A Wyke(5), Andrew W. Stoker(2), Elaine Spooncer(2), Paul J. Simmons(2), Paul Dyson(1), Peter R. Cook(1), T. M. Dexter(1), J. Akroyd(1), Fincham Vj(1), Green Ar(1), P. Levantis(1), Wyke Ja(1), A. R. Green(1), David A. Gillespie(1), Mina J. Bissell(1), John A. Wyke(1), T. M. Dexter(1), Andrew R. Green(1), Candace J. Poole(1), S. Povey(1)