J A Wyke

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index1.6kcitations60works0.02yr avg
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Research Topics

Virus-based gene therapy research(23), Viral Infectious Diseases and Gene Expression in Insects(15), Plant Virus Research Studies(9), Animal Virus Infections Studies(7), Protein Kinase Regulation and GTPase Signaling(4)

Publications60 total

Michael George Parke Stoker
BMJ·2013· 1 cited
Proviral Position Effects: Possible Probes for Genes that Suppress Transcription
Novartis Foundation symposium·2007· 3 cited
Overview — burgeoning promise in metastasis research
European Journal of Cancer·2000· 17 cited
Regulation of both apoptosis and cell survival by the v-Src oncoprotein
Cell Death and Differentiation·2000· 75 citedOpen Access
Expression of the v-Src oncoprotein in fibroblasts disrupts normal regulation of the CDK inhibitor p27 and inhibits quiescence
Oncogene·1998· 51 cited
Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3.
Journal of Medical Genetics·1998· 101 citedOpen Access
Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins.
The Journal of Cell Biology·1996· 178 citedOpen Access
Mitogenesis by v-Src: fluctuations throughout G1 of classical immediate early AP-1 and mitogen-activated protein kinase responses that parallel the need for the oncoprotein.
PubMed·1995· 19 cited
v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts.
PubMed·1995· 84 cited
Mutations in v-Src SH3 and catalytic domains that jointly confer temperature-sensitive transformation with minimal temperature-dependent changes in cellular tyrosine phosphorylation
Journal of Virology·1994· 14 citedOpen Access
Functions of the v‐SRC protein tyrosine kinase
Cell Biology International·1994· 13 cited
Mitogenesis by v-Src: a need for active oncoprotein both in leaving G0 and in completing G1 phases of the cell cycle.
PubMed·1993· 15 cited
Mitogenesis of quiescent chick fibroblasts by v-Src: dependence on events at the membrane leading to early changes in AP-1.
PubMed·1993· 29 cited
On the structure, genesis and significance of DNA duplications at the Rous sarcoma proviral insertion sites in Rat-1 cells
Journal of General Virology·1992· 4 cited
Differences between cellular integration sites of transcribed and nontranscribed Rous sarcoma proviruses
Journal of Virology·1991· 22 citedOpen Access
The second Bagshawe lecture: Matching basic research to the management of cancer: the view from the other side of the fence
British Journal of Cancer·1990· 2 citedOpen Access
Fusion of rous‐sarcoma‐virus‐transformed rat cells to morphologically normal human or rat cells results in transcriptional suppression of the provirus that depends on its chromosomal integration site
International Journal of Cancer·1990· 1 cited
Regulated expression of retroviruses and their oncogenes: models for tumor suppression.
PubMed·1990· 4 cited
Plasma fibronectin in Crohn's disease.
Gut·1989· 24 citedOpen Access
A single point mutation has pleiotropic effects on pp60v-src function
Journal of Virology·1988· 39 citedOpen Access
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Frequent Co-authors

Margaret C. Frame(8), Valerie J. Fincham(7), Andrew W. Stoker(4), David A. Gillespie(4), J. A. Beamand(3), Stuart Kellie(3), S. Searle(3), Anne W. Wyke(3), Mustafa Ünlü(2), Peter R. Cook(2), J.G. Bell(2), D. Gale Johnson(2), A.R. Green(2), David R. Critchley(2), Paul Dyson(2), Andrew D. Catling(2), R N Allan(2), Mina J. Bissell(2), Burkhard Haefner(2), Reinhard Kurth(2)