Christopher M. Treleaven

ProterixBio (United States) — United States

Medicine · Health Sciences

16h-index1.6kcitations23works5.02yr avg
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Research Topics

Lysosomal Storage Disorders Research(10), Amyotrophic Lateral Sclerosis Research(7), Parkinson's Disease Mechanisms and Treatments(5), Neurogenetic and Muscular Disorders Research(5), Sphingolipid Metabolism and Signaling(3)

Publications23 total

Preclinical lentiviral hematopoietic stem cell gene therapy corrects Pompe disease-related muscle and neurological manifestations
Molecular Therapy·2024· 5 citedOpen Access
Preclinical lentiviral vector-mediated hematopoietic stem and progenitor cell gene therapy corrects Pompe disease-related muscle and neurological manifestations
2023Open Access
Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease
Alzheimer s Research & Therapy·2022· 23 citedOpen Access
Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models
Proceedings of the National Academy of Sciences·2017· 196 citedOpen Access
Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson’s disease
Human Molecular Genetics·2016· 55 citedOpen Access
Glucosylceramide synthase inhibition reduces α-synuclein pathology and improves cognition in murine models of synucleinopathy
Molecular Genetics and Metabolism·2016
Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis
Proceedings of the National Academy of Sciences·2015· 130 citedOpen Access
Anti-murine CD52 antibody treatment does not adversely affect the migratory ability of immune cells
Journal of Neuroimmunology·2014· 4 cited
Anti-murine CD52 Antibody Treatment Does Not Adversely Affect the Migratory Ability of Immune Cells (P1.222)
Neurology·2014· 2 cited
Translational Fidelity of Intrathecal Delivery of Self-Complementary AAV9–Survival Motor Neuron 1 for Spinal Muscular Atrophy
Human Gene Therapy·2014· 86 cited
Silencing Mutant Huntingtin by Adeno-Associated Virus-Mediated RNA Interference Ameliorates Disease Manifestations in the YAC128 Mouse Model of Huntington's Disease
Human Gene Therapy·2014· 160 citedOpen Access
Metabolic signatures of amyotrophic lateral sclerosis reveal insights into disease pathogenesis
Proceedings of the National Academy of Sciences·2013· 128 citedOpen Access
Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies
Proceedings of the National Academy of Sciences·2013· 243 citedOpen Access
Gene Transfer to the CNS Is Efficacious in Immune-primed Mice Harboring Physiologically Relevant Titers of Anti-AAV Antibodies
Molecular Therapy·2012· 30 citedOpen Access
Disease progression in a mouse model of amyotrophic lateral sclerosis: the influence of chronic stress and corticosterone
The FASEB Journal·2011· 35 cited
Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion
Experimental Neurology·2011· 33 cited
Comparative Analysis of Acid Sphingomyelinase Distribution in the CNS of Rats and Mice Following Intracerebroventricular Delivery
PLoS ONE·2011· 7 citedOpen Access
Relationship between neuropathology and disease progression in the SOD1G93A ALS mouse
Experimental Neurology·2010· 45 cited
AAV4-mediated Expression of IGF-1 and VEGF Within Cellular Components of the Ventricular System Improves Survival Outcome in Familial ALS Mice
Molecular Therapy·2010· 124 citedOpen Access
Intracerebroventricular infusion of acid sphingomyelinase corrects CNS manifestations in a mouse model of Niemann–Pick A disease
Experimental Neurology·2008· 74 cited
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Frequent Co-authors

Lamya S. Shihabuddin(20), James C. Dodge(18), Seng H. Cheng(17), Tatyana V. Taksir(9), S. Pablo Sardi(7), Thomas J. Tamsett(7), Jonathan A. Fidler(7), Marco A. Passini(5), Richard L. Sidman(5), Jennifer Clarke(4), Catherine Viel(4), Brian K. Kaspar(4), Jie Bu(3), Mark E. Hester(3), Amy M. Richards(2), John Marshall(2), Kuma Misra(2), Amanda M. Haidet(2), Wendy Yang(2), Jennifer Clarke(2)