Elaine Kan

Gilead Sciences (United States) — United States

Immunology and Microbiology · Life Sciences

22h-index1.7kcitations39works0.02yr avg
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Research Topics

HIV Research and Treatment(27), HIV/AIDS drug development and treatment(14), Monoclonal and Polyclonal Antibodies Research(11), Immune Cell Function and Interaction(11), Immunotherapy and Immune Responses(6)

Publications39 total

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor
Bioorganic & Medicinal Chemistry·2018· 16 citedOpen Access
Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile
Antimicrobial Agents and Chemotherapy·2016· 274 citedOpen Access
Graphical Abstract: Angew. Chem. Int. Ed. 5/2016
Angewandte Chemie International Edition·2016Open Access
High-Throughput Screening of Formulations to Optimize the Thermal Stability of a Therapeutic Monoclonal Antibody
SLAS DISCOVERY·2014· 51 citedOpen Access
Structural and Regulatory Elements of HCV NS5B Polymerase – β-Loop and C-Terminal Tail – Are Required for Activity of Allosteric Thumb Site II Inhibitors
PLoS ONE·2014· 34 citedOpen Access
High Throughput Screening of Formulations to Optimize the Thermal Stability of Therapeutic Monoclonal Antibody
Biophysical Journal·2014· 2 citedOpen Access
Regulatory Elements of HCV NS5B Polymerase - β -Loop and C-Terminal Tail - are Required for Activity of Allosteric Thumb Site II Inhibitors
Biophysical Journal·2014Open Access
Putative role of Tat–Env interaction in HIV infection
AIDS·2013· 4 cited
HIV-1 Tat Promotes Integrin-Mediated HIV Transmission to Dendritic Cells by Binding Env Spikes and Competes Neutralization by Anti-HIV Antibodies
PLoS ONE·2012· 56 citedOpen Access
New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action
Journal of Biological Chemistry·2012· 159 citedOpen Access
Supplementary Material 13
2012
Stabilization of HIV-1 envelope in the CD4-bound conformation through specific cross-linking of a CD4 mimetic.
Journal of Biological Chemistry·2011· 1 citedOpen Access
Structural Characteristics Predict the Stability of HIV
2011
Metronidazole leads to enhanced uptake of imatinib in brain, liver and kidney without affecting its plasma pharmacokinetics in mice
Journal of Pharmacy and Pharmacology·2011· 22 cited
Stabilization of HIV-1 Envelope in the CD4-bound Conformation through Specific Cross-linking of a CD4 Mimetic
Journal of Biological Chemistry·2011· 25 citedOpen Access
Quaternary structures of HIV Env immunogen exhibit conformational vicissitudes and interface diminution elicited by ligand binding
Proceedings of the National Academy of Sciences·2011· 31 citedOpen Access
Differential effects of ketoconazole and primaquine on the pharmacokinetics and tissue distribution of imatinib in mice
Anti-Cancer Drugs·2010· 24 cited
Antibody-Mediated Protection against Mucosal Simian-Human Immunodeficiency Virus Challenge of Macaques Immunized with Alphavirus Replicon Particles and Boosted with Trimeric Envelope Glycoprotein in MF59 Adjuvant
Journal of Virology·2010· 84 cited
P04-25. Exposure of HIV-1 pseudovirus to soluble CD4 increases the breadth of neutralization with sera from macaques immunized with recombinant glycoproteins
Retrovirology·2009Open Access
P19-23. Putative prefusion mechanism of HIV-1 Env revealed by ligand-induced quaternary alterations in o-gp140 trimers
Retrovirology·2009Open Access
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Frequent Co-authors

Indresh K. Srivastava(26), Susan W. Barnett(25), Jeffrey B. Ulmer(15), Yide Sun(15), Ying Lian(11), Leonidas Stamatatos(8), Anita Niedziela‐Majka(7), John Donnelly(7), Brian Burke(7), David C. Montefiori(6), Victoria A. Sharma(6), Roman Sakowicz(5), Michael Vajdy(5), Susan Hilt(5), Loı̈c Martin(5), Magdeleine Hung(4), Harold Legg(4), Jan zur Megede(4), Jimna Cisto(4), R. Holland Cheng(4)