Simon N. Haydar

Drug Discovery Laboratory (Norway) — Norway

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index459citations35works0.02yr avg
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Research Topics

Nicotinic Acetylcholine Receptors Study(11), Receptor Mechanisms and Signaling(10), Cholinesterase and Neurodegenerative Diseases(7), Synthesis and Characterization of Heterocyclic Compounds(6), Synthesis and biological activity(5)

Publications35 total

Advancing the development of deep learning and machine learning models for oral drugs through diverse descriptor classes: a focus on pharmacokinetic parameters (Vdss and PPB)
Molecular Diversity·2025
Advancing the development of Deep Learning and Machine Learning models for oral drugs through diverse descriptor classes: A focus on Pharmacokinetic Parameters (Vdss and PPB)
2025Open Access
PS-073-Preclinical profile of HBV core protein inhibitor, ABI-H, a potent inhibitor of cccDNA generation in HBV infected cells
Journal of Hepatology·2019· 5 cited
Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor
European Journal of Medicinal Chemistry·2014· 21 cited
<i>N</i>-[5-(5-Fluoropyridin-3-yl)-1<i>H</i>-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): A Medicinal Chemistry Effort toward an α7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate
Journal of Medicinal Chemistry·2012· 14 citedOpen Access
Discovery of a Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonist Series and Characterization of the Potent, Selective, and Orally Efficacious Agonist 5-(4-Acetyl[1,4]diazepan-1-yl)pentanoic Acid [5-(4-Methoxyphenyl)-1H-pyrazol-3-yl] Amide (SEN15924, WAY-361789)
Journal of Medicinal Chemistry·2012· 26 citedOpen Access
Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625
Psychopharmacology·2011· 20 cited
ChemInform Abstract: Synthesis of Novel 4‐Fluoro‐2H‐pyrazol‐3‐ylamines.
ChemInform·2010
Synthesis of Novel 4-Fluoro-2H-pyrazol-3-ylamines
Synthetic Communications·2010· 9 cited
P3‐329: SAM‐531, N,N‐dimethyl‐3‐{[3‐(1‐naphthylsulfonyl)‐1H‐indazol‐5‐yl]oxy} propan‐1‐amine, a novel serotonin‐6 receptor antagonist with preclinical pro‐cognitive efficacy
Alzheimer s & Dementia·2010· 7 cited
Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonists Containing a Urea Moiety: Identification and Characterization of the Potent, Selective, and Orally Efficacious Agonist 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) Urea (SEN34625/WYE-103914)
Journal of Medicinal Chemistry·2010· 30 citedOpen Access
5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT<sub>6</sub> Receptor Antagonists
Journal of Medicinal Chemistry·2010· 22 citedOpen Access
Neuronal Nicotinic Acetylcholine Receptors - Targets for the Development of Drugs to Treat Cognitive Impairment Associated with Schizophrenia and Alzheimers Disease
Current Topics in Medicinal Chemistry·2010· 94 cited
Corrigendum to “SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist” [Bioorg. Med. Chem. 17 (2009) 5247]
Bioorganic & Medicinal Chemistry·2009
P2.080 Dimebon™ is neuroprotective in a model of Parkinson's disease
Parkinsonism & Related Disorders·2009· 1 cited
1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT6 receptor ligands
Bioorganic & Medicinal Chemistry Letters·2009· 11 citedOpen Access
Heterobiaryl purine derivatives as potent antiproliferative agents: Inhibitors of cyclin dependent kinases. Part II
Bioorganic & Medicinal Chemistry Letters·2009· 16 citedOpen Access
Novel Oxidation of Cyclosporin A: Preparation of Cyclosporin Methyl Vinyl Ketone (Cs-MVK)
Synlett·2009· 5 cited
Characterization of the alpha-7 nicotinic receptor agonist WYE-103914 in models relevant to schizophrenia and interaction with antipsychotics
Biochemical Pharmacology·2009
In vitro pharmacological characterization and pro-cognitive effects of the selective alpha-7 nicotinic agonist WYE-103914
Biochemical Pharmacology·2009
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Frequent Co-authors

Thomas A. Comery(13), Chiara Ghiron(13), John Dunlop(12), Carla Scali(10), A. Paul Krapcho(10), Renza Roncarati(8), Iolanda Micco(8), Riccardo Zanaletti(8), Georg C. Terstappen(6), Hendrick Bothmann(5), Cody Kelley(5), Michela Valacchi(5), Suzan Aschmies(5), Giuseppe Cocconcelli(5), Flora Jow(5), Dianne Kowal(4), Laura Bettinetti(4), Cristiana Castaldo(4), Laura Maccari(4), Karen L. Marquis(4)