Wendell Davis

Alnylam Pharmaceuticals (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index863citations32works0.32yr avg
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Research Topics

RNA Interference and Gene Delivery(6), Advanced biosensing and bioanalysis techniques(5), MicroRNA in disease regulation(4), Renin-Angiotensin System Studies(4), Blood Pressure and Hypertension Studies(2)

Publications32 total

Introducing the Sinclair Nanopig™ model: Preliminary genomic, proteomic, and hepatic CYP450 characterization for (bio)pharmaceutical safety assessment
Journal of Pharmacological and Toxicological Methods·2025
Mechanistic Insights into Hybridization-Based Off-Target Activity of GalNAc-siRNA Conjugates
Nucleic Acid Therapeutics·2025· 1 citedOpen Access
Introducing the Sinclair Nanopig™ Model: Preliminary Genomic, Proteomic, and Hepatic Cyp450 Characterization for (Bio)Pharmaceutical Safety Assessment
SSRN Electronic Journal·2025Open Access
From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization
Nucleic Acids Research·2022· 84 citedOpen Access
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates
Nature Biotechnology·2022· 225 citedOpen Access
Expanding the Reach of RNAi Therapeutics with Next Generation Lipophilic siRNA Conjugates
2021· 3 citedOpen Access
International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog
Toxicologic Pathology·2021· 40 cited
Nonclinical Safety Profile of Revusiran, a 1st-Generation GalNAc-siRNA Conjugate for Treatment of Hereditary Transthyretin-Mediated Amyloidosis
Nucleic Acid Therapeutics·2019· 21 citedOpen Access
Incidental Ultrastructural Findings in the Sural Nerve and Dorsal Root Ganglion of Aged Control Sprague Dawley Rats in a Nonclinical Carcinogenicity Study
Toxicologic Pathology·2019· 7 citedOpen Access
Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates
Nucleic Acids Research·2019· 77 citedOpen Access
Development of Liver-Specific Thrombopoietin Targeted Sirnas: Impact on Platelet Count, Megakaryocyte Mass, and Hematopoietic Progenitors in Normal and MPN Murine Models
Blood·2018· 2 cited
Microscopic Background Changes in Brains of Cynomolgus Monkeys
Toxicologic Pathology·2014· 10 cited
Physiological stress increases renal injury in eNOS-knockout mice
Hypertension Research·2011· 8 citedOpen Access
The effect of salt on renal damage in eNOS-deficient mice
Hypertension Research·2009· 11 citedOpen Access
Protective Effect of BG9928, an Adenosine Receptor Antagonist, against Cisplatin‐Induced Acute Renal Injury in Rats: Comparison with Furosemide
The FASEB Journal·2009
Protective Effect of Tonapofylline (BG9928), an Adenosine A<sub>1</sub> Receptor Antagonist, against Cisplatin-Induced Acute Kidney Injury in Rats
American Journal of Nephrology·2009· 25 cited
The effect of hypotonicity on the mean platelet volume of patients with thrombo-embolism
Clinical & Laboratory Haematology·2008· 3 cited
Automated differential count rejections and in vitro platelet aggregation in blood from patients taking warfarin
Clinical & Laboratory Haematology·2008· 1 cited
Temporal-spatial expression of ANG-(1-7) and angiotensin-converting enzyme 2 in the kidney of normal and hypertensive pregnant rats
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology·2007· 87 cited
Different Effects of Angiotensin Receptor Blockade on End-Organ Damage in Salt-Dependent and Salt-Independent Hypertension
Circulation·2006· 17 citedOpen Access
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Frequent Co-authors

Maja M. Janas(5), Saket Agarwal(5), Jessica E. Sutherland(5), Christopher R. Brown(4), Yongfeng Jiang(4), Mark K. Schlegel(4), Klaus Charissé(4), Kevin Fitzgerald(4), Martin A. Maier(4), Vasant Jadhav(4), Jayaprakash K. Nair(3), Jing Li(3), Shigeo Matsuda(3), Jason A. Gilbert(3), Tuyen Nguyen(3), Arlin B. Rogers(3), Adam Castoreno(3), Stuart Milstein(3), Ivan Zlatev(3), Muthiah Manoharan(3)