Maja M. Janas

Alnylam Pharmaceuticals (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index2.7kcitations28works1.02yr avg
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Research Topics

RNA Interference and Gene Delivery(17), MicroRNA in disease regulation(16), Advanced biosensing and bioanalysis techniques(15), RNA modifications and cancer(8), RNA Research and Splicing(7)

Publications28 total

Mechanistic Insights into Hybridization-Based Off-Target Activity of GalNAc-siRNA Conjugates
Nucleic Acid Therapeutics·2025· 1 citedOpen Access
Shorter Is Better: The α-(<scp>l</scp>)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs
Journal of the American Chemical Society·2023· 37 citedOpen Access
Evaluation of RNAi therapeutics VIR-2218 and ALN-HBV for chronic hepatitis B: Results from randomized clinical trials
Journal of Hepatology·2023· 89 citedOpen Access
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex
Chemical Communications·2023· 9 cited
Role of a “Magic” Methyl: 2′-Deoxy-2′-α-F-2′-β-<i>C</i>-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5′-Phosphate Mimics and Mitigation of Off-Target Effects
Journal of the American Chemical Society·2022· 30 citedOpen Access
From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization
Nucleic Acids Research·2022· 84 citedOpen Access
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates
Nature Biotechnology·2022· 225 citedOpen Access
Expanding the Reach of RNAi Therapeutics with Next Generation Lipophilic siRNA Conjugates
2021· 3 citedOpen Access
The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
Drug Metabolism and Disposition·2021· 97 citedOpen Access
Impact of Serum Proteins on the Uptake and RNAi Activity of GalNAc-Conjugated siRNAs
Nucleic Acid Therapeutics·2021· 22 citedOpen Access
siRNAs containing 2′-fluorinated <i>Northern</i>-methanocarbacyclic (2′-F-NMC) nucleotides: <i>in vitro</i> and <i>in vivo</i> RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs
Nucleic Acids Research·2021· 19 citedOpen Access
Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease
Nucleic Acids Research·2020· 42 citedOpen Access
Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates
Nucleic Acids Research·2019· 77 citedOpen Access
The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies
Toxicologic Pathology·2018· 74 citedOpen Access
Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
Nature Communications·2018· 255 citedOpen Access
Impact of Oligonucleotide Structure, Chemistry, and Delivery Method on <i>In Vitro</i> Cytotoxicity
Nucleic Acid Therapeutics·2016· 42 cited
Exposure to siRNA-GalNAc Conjugates in Systems of the Standard Test Battery for Genotoxicity
Nucleic Acid Therapeutics·2016· 26 cited
Mechanisms of RNA loading into exosomes
FEBS Letters·2015· 385 cited
Transcription Factor/microRNA Axis Blocks Melanoma Invasion Program by miR-211 Targeting NUAK1
Journal of Investigative Dermatology·2013· 121 citedOpen Access
Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets
Molecular Cell·2013· 158 citedOpen Access
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Frequent Co-authors

Yongfeng Jiang(12), Muthiah Manoharan(10), Mark K. Schlegel(9), Saket Agarwal(9), Ivan Zlatev(8), Martin A. Maier(8), Carl D. Novina(7), Vasant Jadhav(7), Klaus Charissé(7), Adam Castoreno(6), Shigeo Matsuda(6), Martin Egli(6), Christopher S. Theile(5), Christopher R. Brown(5), Dale C. Guenther(5), Jason A. Gilbert(5), Wendell Davis(5), Kevin Fitzgerald(5), Jing‐Tao Wu(5), Jayaprakash K. Nair(4)