Dale C. Guenther

Alnylam Pharmaceuticals (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index936citations32works3.32yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Advanced biosensing and bioanalysis techniques(28), DNA and Nucleic Acid Chemistry(24), RNA Interference and Gene Delivery(21), RNA and protein synthesis mechanisms(3), CRISPR and Genetic Engineering(3)

Publications32 total

Modified unlocked nucleic acid (MUNA) mitigates off-target effects of small interfering RNAs
Nucleic Acids Research·2025Open Access
Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway
Journal of the American Chemical Society·2024· 1 cited
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates
Nucleic Acids Research·2024· 9 citedOpen Access
Shorter Is Better: The α-(<scp>l</scp>)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs
Journal of the American Chemical Society·2023· 37 citedOpen Access
Role of a “Magic” Methyl: 2′-Deoxy-2′-α-F-2′-β-<i>C</i>-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5′-Phosphate Mimics and Mitigation of Off-Target Effects
Journal of the American Chemical Society·2022· 30 citedOpen Access
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates
Nature Biotechnology·2022· 225 citedOpen Access
Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing
Nucleic Acids Research·2021· 22 citedOpen Access
The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
Drug Metabolism and Disposition·2021· 97 citedOpen Access
Recognition of double-stranded DNA using LNA-modified toehold Invader probes
Organic & Biomolecular Chemistry·2021· 9 citedOpen Access
Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease
Nucleic Acids Research·2020· 42 citedOpen Access
Impact of non-nucleotidic bulges on recognition of mixed-sequence dsDNA by pyrene-functionalized Invader probes
Organic & Biomolecular Chemistry·2020· 1 citedOpen Access
Head-to-head comparison of LNA, <sup>MP</sup>γPNA, INA and Invader probes targeting mixed-sequence double-stranded DNA
Organic & Biomolecular Chemistry·2019· 17 cited
Synthesis and biophysical characterization of oligonucleotides modified with O2′-alkylated RNA monomers featuring substituted pyrene moieties
Organic & Biomolecular Chemistry·2018· 4 cited
Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance, thermal stability and RNAi activity
Nucleic Acids Research·2018· 44 citedOpen Access
4′-<i>C</i>-Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing
Journal of the American Chemical Society·2017· 65 cited
Recognition of mixed-sequence DNA using double-stranded probes with interstrand zipper arrangements of O2′-triphenylene- and coronene-functionalized RNA monomers
Organic & Biomolecular Chemistry·2017· 6 citedOpen Access
Bulged Invader probes: activated duplexes for mixed-sequence dsDNA recognition with improved thermodynamic and kinetic profiles
Chemical Communications·2015· 18 cited
Invader probes: harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications
Chemical Science·2015· 29 citedOpen Access
Carbohydrate-Functionalized Locked Nucleic Acids: Oligonucleotides with Extraordinary Binding Affinity, Target Specificity, and Enzymatic Stability
Organic Letters·2014· 13 cited
C5-Alkynyl-Functionalized α-L-LNA: Synthesis, Thermal Denaturation Experiments and Enzymatic Stability
The Journal of Organic Chemistry·2014· 8 citedOpen Access
page 1 of 2Next →

Frequent Co-authors

Patrick J. Hrdlicka(20), Saswata Karmakar(12), Muthiah Manoharan(11), Ivan Zlatev(9), Pawan Kumar(9), Martin A. Maier(8), Martin Egli(8), Shigeo Matsuda(7), Klaus Charissé(7), Brooke A. Anderson(7), Adam Castoreno(6), Michael E. Østergaard(6), Maja M. Janas(5), Christopher S. Theile(5), Joel M. Harp(5), Anna Bisbe(5), Bharat Baral(5), Pawan K. Sharma(5), Saket Agarwal(4), Yongfeng Jiang(4)