Brooke A. Anderson

Ionis Pharmaceuticals (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index694citations30works10.02yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(21), Advanced biosensing and bioanalysis techniques(20), RNA Interference and Gene Delivery(16), RNA and protein synthesis mechanisms(5), CRISPR and Genetic Engineering(2)

Publications30 total

Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles
Nucleic Acids Research·2025· 10 citedOpen Access
Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics
Nucleic Acids Research·2023· 22 citedOpen Access
Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding
Nucleic Acids Research·2022· 13 citedOpen Access
Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides
Nucleic Acids Research·2021· 121 citedOpen Access
Frontispiece: The Unexpected Base‐Pairing Behavior of Cyanuric Acid in RNA and Ribose versus Cyanuric Acid Induced Helicene Assembly of Nucleic Acids: Implications for the Pre‐RNA Paradigm
Chemistry - A European Journal·2021Open Access
The Unexpected Base‐Pairing Behavior of Cyanuric Acid in RNA and Ribose versus Cyanuric Acid Induced Helicene Assembly of Nucleic Acids: Implications for the Pre‐RNA Paradigm
Chemistry - A European Journal·2020· 21 cited
Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins
Journal of the American Chemical Society·2020· 89 cited
Nanopore Sequencing of an Expanded Genetic Alphabet Reveals High-Fidelity Replication of a Predominantly Hydrophobic Unnatural Base Pair
Journal of the American Chemical Society·2020· 37 citedOpen Access
Optimization of Replication, Transcription, and Translation in a Semi-Synthetic Organism
Journal of the American Chemical Society·2019· 67 citedOpen Access
Synthesis of Fluorescence Turn‐On DNA Hybridization Probe Using the <sup>DEA</sup>tC 2′‐Deoxycytidine Analog
Current Protocols in Nucleic Acid Chemistry·2018· 2 cited
Heterogeneous Pyrophosphate‐Linked DNA–Oligonucleotides: Aversion to DNA but Affinity for RNA
Chemistry - A European Journal·2018· 13 cited
Merging Two Strategies for Mixed-Sequence Recognition of Double-Stranded DNA: Pseudocomplementary Invader Probes
The Journal of Organic Chemistry·2016· 12 citedOpen Access
Next-generation bis-locked nucleic acids with stacking linker and 2′-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes
Nucleic Acids Research·2016· 31 citedOpen Access
Synthesis and characterization of oligodeoxyribonucleotides modified with 2′-thio-2′-deoxy-2′-S-(pyren-1-yl)methyluridine
Bioorganic & Medicinal Chemistry Letters·2015· 6 citedOpen Access
Recognition of Double-Stranded DNA Using Energetically Activated Duplexes Modified with N2′-Pyrene-, Perylene-, or Coronene-Functionalized 2′-<i>N</i>-Methyl-2′-amino-DNA Monomers
The Journal of Organic Chemistry·2015· 15 cited
Invader probes: harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications
Chemical Science·2015· 29 citedOpen Access
ChemInform Abstract: Synthesis and Characterization of Oligodeoxyribonucleotides Modified with 2′‐Amino‐α‐L‐LNA Adenine Monomers: High‐Affinity Targeting of Single‐Stranded DNA.
ChemInform·2014
C5-Alkynyl-Functionalized α-L-LNA: Synthesis, Thermal Denaturation Experiments and Enzymatic Stability
The Journal of Organic Chemistry·2014· 8 citedOpen Access
Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid)
The Journal of Organic Chemistry·2014· 31 citedOpen Access
C5-Amino acid functionalized LNA: positively poised for antisense applications
Chemical Communications·2014· 12 citedOpen Access
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Frequent Co-authors

Patrick J. Hrdlicka(16), Michael E. Østergaard(8), Pawan Kumar(8), Dale C. Guenther(7), Pawan K. Sharma(6), Punit P. Seth(5), Ramanarayanan Krishnamurthy(5), Bharat Baral(5), Nicolai K. Andersen(4), Jesper Wengel(4), Saswata Karmakar(3), Lee A. Deobald(3), Andrzej Paszczyński(3), Graeme C. Freestone(2), Wei Wan(2), Timothy A. Vickers(2), Stanley T. Crooke(2), Eric E. Swayze(2), Xue‐hai Liang(2), Malwina Hyjek‐Składanowska(2)