Christopher S. Theile

Alnylam Pharmaceuticals (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index2.1kcitations43works4.32yr avg
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Research Topics

RNA Interference and Gene Delivery(17), Advanced biosensing and bioanalysis techniques(16), DNA and Nucleic Acid Chemistry(10), Biochemical and Structural Characterization(9), MicroRNA in disease regulation(5)

Publications43 total

Expanding the binding space of argonaute-2: incorporation of either <i>E</i> or <i>Z</i> isomers of 6′-vinylphosphonate at the 5′ end of the antisense strand improves RNAi activity
Chemical Communications·2025· 3 cited
Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway
Journal of the American Chemical Society·2024· 1 cited
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates
Nucleic Acids Research·2024· 9 citedOpen Access
Shorter Is Better: The α-(<scp>l</scp>)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs
Journal of the American Chemical Society·2023· 37 citedOpen Access
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex
Chemical Communications·2023· 9 cited
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates
Nature Biotechnology·2022· 225 citedOpen Access
Expanding the Reach of RNAi Therapeutics with Next Generation Lipophilic siRNA Conjugates
2021· 3 citedOpen Access
The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
Drug Metabolism and Disposition·2021· 97 citedOpen Access
Centyrin ligands for extrahepatic delivery of siRNA
Molecular Therapy·2021· 45 citedOpen Access
Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates
Nucleic Acids Research·2020· 265 citedOpen Access
Turnip yellow mosaic virus protease binds ubiquitin suboptimally to fine-tune its deubiquitinase activity
Journal of Biological Chemistry·2020· 11 citedOpen Access
Generation and validation of structurally defined antibody–siRNA conjugates
Nucleic Acids Research·2020· 51 citedOpen Access
An efficient deprotection method for 5′-[O,O-bis(pivaloyloxymethyl)]-(E)-vinylphosphonate containing oligonucleotides
Tetrahedron·2018· 22 cited
Facile Synthesis, Geometry, and 2′-Substituent-Dependent in Vivo Activity of 5′-(<i>E</i>)- and 5′-(<i>Z</i>)-Vinylphosphonate-Modified siRNA Conjugates
Journal of Medicinal Chemistry·2018· 54 cited
siRNA carrying an (E)-vinylphosphonate moiety at the 5′ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2
Nucleic Acids Research·2016· 5 citedOpen Access
siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2
Nucleic Acids Research·2016· 85 citedOpen Access
Rapid capture and labeling of cells on single domain antibodies-functionalized flow cell
Biosensors and Bioelectronics·2016· 7 citedOpen Access
Inside Cover: 5′‐(<i>E</i>)‐Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA–GalNAc Conjugates (ChemBioChem 11/2016)
ChemBioChem·2016Open Access
5′‐(<i>E</i>)‐Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA–GalNAc Conjugates
ChemBioChem·2016· 132 cited
Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling
Proceedings of the National Academy of Sciences·2016· 51 citedOpen Access
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Frequent Co-authors

Hidde L. Ploegh(16), Muthiah Manoharan(15), Martin A. Maier(12), Ivan Zlatev(9), Vasant Jadhav(9), Larry W. McLaughlin(9), Martin D. Witte(8), Klaus Charissé(8), Carla P. Guimarães(7), Annet E. M. Blom(7), Christopher R. Brown(7), Rubina Parmar(7), Shigeo Matsuda(6), Jayaprakash K. Nair(6), Zeyang Li(6), Lenka Kundrat(5), June Qin(5), Maja M. Janas(5), Donald J. Foster(5), Dale C. Guenther(5)