Raphael Darcy

University College Cork — Ireland

Biochemistry, Genetics and Molecular Biology · Life Sciences

36h-index3.2kcitations70works0.02yr avg
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Research Topics

RNA Interference and Gene Delivery(25), Advanced biosensing and bioanalysis techniques(16), Surfactants and Colloidal Systems(11), Nanoparticle-Based Drug Delivery(10), Drug Solubulity and Delivery Systems(9)

Publications70 total

Self-Assembled Cationic β-Cyclodextrin Nanostructures for siRNA Delivery
Molecular Pharmaceutics·2019· 58 citedOpen Access
Cyclodextrin-siRNA conjugates as versatile gene silencing agents
European Journal of Pharmaceutical Sciences·2017· 33 citedOpen Access
Folate-targeted amphiphilic cyclodextrin nanoparticles incorporating a fusogenic peptide deliver therapeutic siRNA and inhibit the invasive capacity of 3D prostate cancer tumours
International Journal of Pharmaceutics·2017· 34 citedOpen Access
Antibody-Targeted Cyclodextrin-Based Nanoparticles for siRNA Delivery in the Treatment of Acute Myeloid Leukemia: Physicochemical Characteristics, <i>in Vitro</i> Mechanistic Studies, and <i>ex Vivo</i> Patient Derived Therapeutic Efficacy
Molecular Pharmaceutics·2017· 67 cited
Formulation and Evaluation of Anisamide-Targeted Amphiphilic Cyclodextrin Nanoparticles To Promote Therapeutic Gene Silencing in a 3D Prostate Cancer Bone Metastases Model
Molecular Pharmaceutics·2016· 50 cited
Oligonucleotide conjugates – Candidates for gene silencing therapeutics
European Journal of Pharmaceutics and Biopharmaceutics·2016· 34 cited
Nanoparticle-mediated siRNA delivery assessed in a 3D co-culture model simulating prostate cancer bone metastasis
International Journal of Pharmaceutics·2016· 36 cited
Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo
Nanomedicine Nanotechnology Biology and Medicine·2016· 55 cited
A novel, anisamide-targeted cyclodextrin nanoformulation for siRNA delivery to prostate cancer cells expressing the sigma-1 receptor
International Journal of Pharmaceutics·2015· 77 cited
The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics
Biomaterials·2015· 112 cited
Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: In vitro analysis
European Journal of Pharmaceutical Sciences·2015· 67 cited
PEGylated cyclodextrins as novel siRNA nanosystems: Correlations between polyethylene glycol length and nanoparticle stability
International Journal of Pharmaceutics·2014· 51 cited
Biophysical and Structural Characterisation of Nucleic Acid Complexes with Modified Cyclodextrins Using Circular Dichroism
Journal of Pharmaceutical Sciences·2014· 14 cited
Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system
Biomaterials·2013· 38 citedOpen Access
Gastrointestinal gene delivery by cyclodextrins – In vitro quantification of extracellular barriers
International Journal of Pharmaceutics·2013· 16 cited
Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery
PLoS ONE·2013· 35 citedOpen Access
Nanostructures of Cationic Amphiphilic Cyclodextrin Complexes with DNA
Biomacromolecules·2013· 54 cited
Cyclodextrins for Non-Viral Gene and siRNA Delivery
Pharmaceutical Nanotechnology·2012· 2 cited
Cyclodextrins for Non-Viral Gene and siRNA Delivery
Pharmaceutical Nanotechnology·2012· 23 citedOpen Access
In Vitro Investigations of the Efficacy of Cyclodextrin-siRNA Complexes Modified with Lipid-PEG-Octaarginine: Towards a Formulation Strategy for Non-viral Neuronal siRNA Delivery
Pharmaceutical Research·2012· 41 cited
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Frequent Co-authors

Caitríona M. O’Driscoll(24), Bart Jan Ravoo(10), Antonino Mazzaglia(10), John F. Cryan(9), Jianfeng Guo(8), Julien Ogier(8), Meenakshi Malhotra(8), James Evans(7), Ruth Donohue(6), Aoife O’Mahony(6), Bruno M.D.C. Godinho(5), Matt Gooding(5), Kathleen A. Fitzgerald(4), Florence Sallas(3), Stéphane Desgranges(3), Caroline M. Curtin(3), Pascale Schwinté(3), C.J. Byrne(3), Michael F. Cronin(3), Aoife Quinlan(3)