Michael C. Keefer

University of Rochester — United States

Immunology and Microbiology · Life Sciences

44h-index5.4kcitations147works5.72yr avg
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Research Topics

HIV Research and Treatment(85), Immune Cell Function and Interaction(33), vaccines and immunoinformatics approaches(29), HIV/AIDS Research and Interventions(25), Immunotherapy and Immune Responses(20)

Publications142 total

A polyvalent DNA prime with matched polyvalent protein/GLA-SE boost regimen elicited the most robust and broad IgG and IgG3 V1V2 binding antibody and CD4+ T cell responses among 13 HIV vaccine trials
Emerging Microbes & Infections·2025· 1 citedOpen Access
Deciphering HIV vaccine-induced antibody response according to ethnicity
AIDS·2025· 1 citedOpen Access
Sirolimus reduces T cell cycling, immune checkpoint marker expression, and HIV-1 DNA in people with HIV
Cell Reports Medicine·2024· 7 citedOpen Access
SWIFT clustering analysis of intracellular cytokine staining flow cytometry data of the HVTN 105 vaccine trial reveals high frequencies of HIV-specific CD4+ T cell responses and associations with humoral responses
Frontiers in Immunology·2024· 1 citedOpen Access
HIV BG505 SOSIP.664 trimer with 3M-052-AF/alum induces human autologous tier-2 neutralizing antibodies
2024· 6 citedOpen Access
Safety and immunogenicity of a polyvalent DNA–protein HIV vaccine with matched Env immunogens delivered as a prime–boost regimen or coadministered in HIV-uninfected adults in the USA (HVTN 124): a phase 1, placebo-controlled, double-blind randomised controlled trial
The Lancet HIV·2024· 9 citedOpen Access
Predictors of HIV rebound differ by timing of antiretroviral therapy initiation
JCI Insight·2024· 19 citedOpen Access
Polytopic fractional delivery of an HIV vaccine alters cellular responses and results in increased epitope breadth in a phase 1 randomized trial
EBioMedicine·2024· 5 citedOpen Access
Protein Dose-Sparing Effect of AS01B Adjuvant in a Randomized Preventive HIV Vaccine Trial of ALVAC-HIV (vCP2438) and Adjuvanted Bivalent Subtype C gp120
The Journal of Infectious Diseases·2023· 6 citedOpen Access
Daily fosfomycin versus levofloxacin for complicated urinary tract infections
mBio·2023· 5 citedOpen Access
Mixed Origins: HIV gp120-Specific Memory Develops from Pre-Existing Memory and Naive B Cells Following Vaccination in Humans
AIDS Research and Human Retroviruses·2023· 4 citedOpen Access
Safety and Immunogenicity of Ad26-Vectored HIV Vaccine With Mosaic Immunogens and a Novel Mosaic Envelope Protein in HIV-Uninfected Adults: A Phase 1/2a Study
The Journal of Infectious Diseases·2022· 33 citedOpen Access
Baseline host determinants of robust human HIV-1 vaccine-induced immune responses: A meta-analysis of 26 vaccine regimens
EBioMedicine·2022· 11 citedOpen Access
HIV gp120-specific memory develops from pre-existing memory and naive B cells following vaccination in humans
The Journal of Immunology·2022
Baseline Host Determinants of Robust Human HIV-1 Vaccine- Induced Immune Responses: A Meta-Analysis of 26 Vaccine Regimens
SSRN Electronic Journal·2022· 1 citedOpen Access
Sequence and vector shapes vaccine induced antibody effector functions in HIV vaccine trials
PLoS Pathogens·2021· 2 citedOpen Access
CD4+ T Cells Are Dispensable for Induction of Broad Heterologous HIV Neutralizing Antibodies in Rhesus Macaques
Frontiers in Immunology·2021· 1 citedOpen Access
Safety and immunogenicity of a SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant in healthy adults: interim findings from a phase 2, randomised, dose-finding, multi-centre study
2021· 2 citedOpen Access
Mixed Origins: HIV gp120-specific memory develops from pre-existing memory and naïve B cells following vaccination in humans
2021· 1 citedOpen Access
AIDSVAX protein boost improves breadth and magnitude of vaccine-induced HIV-1 envelope-specific responses after a 7-year rest period
Vaccine·2021· 2 citedOpen Access
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Frequent Co-authors

David C. Montefiori(21), M. Juliana McElrath(21), Lawrence Corey(20), Barney S. Graham(18), Mark J. Mulligan(14), Kent J. Weinhold(14), Georgia D. Tomaras(11), Geoffrey J. Gorse(11), Patricia Fast(10), Paul A. Goepfert(10), Susan Buchbinder(8), Lindsey R. Baden(8), Sharon E. Frey(8), David H. Schwartz(8), Beryl A. Koblin(7), Guido Ferrari(7), Robert B. Belshe(7), Spyros A. Kalams(6), Marnie Elizaga(6), Thomas G. Evans(6)