Jiansong Xie

Amgen (United States) — United States

Medicine · Health Sciences

17h-index996citations46works3.52yr avg
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Research Topics

Ocular Surface and Contact Lens(12), Cellular transport and secretion(10), Salivary Gland Disorders and Functions(9), Liver Disease Diagnosis and Treatment(4), Cell Adhesion Molecules Research(4)

Publications46 total

PNPLA3-I148M is a neomorph that interferes with two primary hepatic triglyceride clearance pathways
Cell Reports·2025Open Access
LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation
Nature Communications·2025· 4 citedOpen Access
Abstract 2651 PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways
Journal of Biological Chemistry·2025Open Access
PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways
2024· 1 citedOpen Access
LYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation
2024Open Access
RAB18 regulates extrahepatic siRNA-mediated gene silencing efficacy
Molecular Therapy — Nucleic Acids·2024Open Access
The fatty liver disease–causing protein PNPLA3-I148M alters lipid droplet–Golgi dynamics
Proceedings of the National Academy of Sciences·2024· 23 citedOpen Access
RAB18 Regulates Extrahepatic SiRNA-Mediated Gene Silencing Efficacy
2024Open Access
The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics
2023· 8 citedOpen Access
Use of In Vitro Human Skin Models to Assess Potential Immune Activation In Response to Biotherapeutic Attributes and Process-related Impurities
Journal of Pharmaceutical Sciences·2022· 8 cited
Transduced viral IL-10 is exocytosed from lacrimal acinar secretory vesicles in a myosin-dependent manner in response to carbachol
UNC Libraries·2020Open Access
Impact of Precipitation of Antibody Therapeutics After Subcutaneous Injection on Pharmacokinetics and Immunogenicity
Journal of Pharmaceutical Sciences·2019· 26 cited
Novel protein therapeutic joint retention strategy based on collagen‐binding Avimers
Journal of Orthopaedic Research®·2017· 20 citedOpen Access
Three‐Dimensional Second‐Harmonic Generation Imaging of Fibrillar Collagen in Biological Tissues
Current Protocols in Cytometry·2012· 3 cited
P-0199 Mechanisms Mediating The Negative Interaction Between Oxaliplatin and Epidermal Growth Factor Receptor Inhibitors in Patients With KRAS Mutant Colorectal Cancer
Annals of Oncology·2012
Mechanisms mediating the negative interaction between oxaliplatin (Ox) and epidermal growth factor receptor (EGFR) inhibitors in patients (pts) with <i>KRAS</i> mutant (MT) colorectal cancer (CRC).
Journal of Clinical Oncology·2012· 1 cited
Abstract A150: Molecular mechanisms mediating the pharmacodynamic interactions between oxaliplatin (Ox) and epidermal growth factor receptor (EGFR) inhibitors in <i>KRAS</i> mutant colorectal cancer (CRC) cells.
Molecular Cancer Therapeutics·2011· 1 cited
Isolated rat heart assay: Validation and potential uses in cardiac safety assessment
Journal of Pharmacological and Toxicological Methods·2011
Intracellular Uptake and Trafficking of Difluoroboron Dibenzoylmethane−Polylactide Nanoparticles in HeLa Cells
ACS Nano·2010· 63 cited
Abstract LB-306: U3-1287 (AMG 888), a fully human anti-HER3 mAb, inhibits HER3 activation and induces HER3 internalization and degradation
Cancer Research·2010· 4 cited
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Frequent Co-authors

Sarah F. Hamm‐Alvarez(22), Austin K. Mircheff(15), John Ferbas(10), Limin Qian(9), Katja Schenke‐Layland(7), Ingrid C. Rulifson(7), Gloria Juan(6), W. Robb MacLellan(5), Limin Qian(5), Raymond J. Deshaies(5), Francie A. Yarber(4), David J. Sherman(4), Selam Ogbagabriel(4), Robert Radinsky(4), Daniel J. Freeman(4), Danielle Pruitt(4), Jose Barreda(4), Kelvin G.M. Brockbank(3), Ekaterini Angelis(3), Kaijin Wu(3)