Hans-Ulrich Demuth

Fraunhofer Institute for Cell Therapy and Immunology — Germany

Medicine · Health Sciences

12h-index971citations15works0.02yr avg
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Research Topics

Peptidase Inhibition and Analysis(9), Diabetes Treatment and Management(7), Neuropeptides and Animal Physiology(7), Alzheimer's disease research and treatments(2), Pancreatic function and diabetes(2)

Publications14 total

Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer’s Disease
Biochemistry·2020· 14 cited
QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain
Frontiers in Neuroinformatics·2019· 137 citedOpen Access
The Proteolytic Profile of Human Cancer Procoagulant Suggests That It Promotes Cancer Metastasis at the Level of Activation Rather Than Degradation
The Protein Journal·2015· 7 cited
Pyroglutamate-3 Amyloid-β Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease–Like Transgenic Mouse Models
American Journal Of Pathology·2013· 113 citedOpen Access
Structure of glutaminyl cyclase from<i>Drosophila melanogaster</i>in space group<i>I</i>4
Acta Crystallographica Section F Structural Biology and Crystallization Communications·2013· 2 citedOpen Access
Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions
Clinical Chemistry and Laboratory Medicine (CCLM)·2009· 44 cited
Glucose-dependent Insulinotropic Polypeptide (GIP): Development of DP IV-Resistant Analogues with Therapeutic Potential
Kluwer Academic Publishers eBooks·2005· 14 cited
A Rapid in Vitro Screening for Delivery of Peptide-Derived Peptidase Inhibitors as Potential Drug Candidates via Epithelial Peptide Transporters
Journal of Pharmacology and Experimental Therapeutics·2004· 16 cited
Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats
Diabetes·2003· 334 citedOpen Access
The expression of T-cell surface antigens CTLA-4, CD26, and CD28 is modulated by inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity in murine stress-induced abortions
Cellular Immunology·2002· 12 cited
Immunoprecipitation and liquid chromatographic–mass spectrometric determination of the peptide glucose-dependent insulinotropic polypeptides GIP1-42 and GIP3-42 from human plasma samples
Journal of Chromatography A·2001· 39 cited
Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP)
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology·2001· 81 cited
Thioxo amino acid pyrrolidides and thiazolidides: new inhibitors of proline specific peptidases
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology·2000· 40 cited
Dipeptidyl Peptidase IV (DPIV/CD26) Degradation of Glucagon
Journal of Biological Chemistry·2000· 118 citedOpen Access

Frequent Co-authors

Christopher H.S. McIntosh(4), Raymond A. Pederson(4), Torsten Hoffmann(4), Nathalie Pamir(3), Simon A. Hinke(3), J. Andrew Pospisilik(2), Jan A. Ehses(2), Francis C. Lynn(2), Kerstin Kühn‐Wache(2), Stephan Schilling(2), Susanne Manhart(2), Leona Wagner(2), Raik Wolf(2), Fred Rosche(2), Jens‐Ulrich Rahfeld(2), Jennifer Martin(1), Timothy Doty(1), Shalea Piteau(1), Sharon C. Yates(1), N. E. Groeneboom(1)