Robert A. Love

Pfizer (United States) — United States

Medicine · Health Sciences

20h-index2.9kcitations36works0.02yr avg
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Research Topics

Hepatitis C virus research(9), RNA and protein synthesis mechanisms(6), Marine Toxins and Detection Methods(6), Biochemical and Molecular Research(6), Viral Infections and Immunology Research(5)

Publications36 total

Identification of Cys255 in HIF‐1α as a novel site for development of covalent inhibitors of HIF‐1α/ARNT PasB domain protein–protein interaction
Protein Science·2012· 79 citedOpen Access
Homodimerization of the PAS-B Domains of Hypoxia-Inducible Factors
The Journal of Physical Chemistry B·2012· 6 citedOpen Access
Development of hepatitis C virus chimeric replicons for identifying broad spectrum NS3 protease inhibitors
Antiviral Research·2011· 12 cited
Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics
Journal of Computer-Aided Molecular Design·2011· 61 cited
Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site
Structure·2009· 142 citedOpen Access
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
Journal of Virology·2009· 230 citedOpen Access
Structure of the Catalytic Domain of Human Protein Kinase C β II Complexed with a Bisindolylmaleimide Inhibitor
Biochemistry·2006· 113 cited
Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors
Bioorganic & Medicinal Chemistry Letters·2006· 54 citedOpen Access
The Crystal Structure of the RNA-Dependent RNA Polymerase from Human Rhinovirus
Structure·2004· 99 citedOpen Access
Crystal structure of RNA-dependent RNA polymerase 3D from human rhinovirus serotype 1B
2004
Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme
Journal of Virology·2003· 8 citedOpen Access
Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme
Journal of Virology·2003· 143 citedOpen Access
Crystal structure of HCV NS5B RNA polymerase complexed with a novel non-competitive inhibitor.
2003
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
Proceedings of the National Academy of Sciences·1999· 316 cited
Interaction of a Novel GDP Exchange Inhibitor with the Ras Protein
Biochemistry·1998· 48 cited
In Replay
Academic Emergency Medicine·1998Open Access
The conformation of hepatitis C virus NS3 proteinase with and without NS4A: a structural basis for the activation of the enzyme by its cofactor
Clinical and Diagnostic Virology·1998· 42 cited
Tripeptide Aldehyde Inhibitors of Human Rhinovirus 3C Protease:  Design, Synthesis, Biological Evaluation, and Cocrystal Structure Solution of P<sub>1</sub> Glutamine Isosteric Replacements
Journal of Medicinal Chemistry·1998· 88 citedOpen Access
HEPATITIS C VIRUS NS3 PROTEINASE
1997· 1 cited
ChemInform Abstract: Design, Synthesis, and Evaluation of Nonpeptidic Inhibitors of Human Rhinovirus 3C Protease.
ChemInform·1997
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Frequent Co-authors

Shella A. Fuhrman(11), Hans E. Parge(9), Peter S. Dragovich(7), Rose Ann Ferre(6), Michael J. Hickey(6), Robert M. Stroud(6), Wade Diehl(6), Amy K. Patick(5), Thomas F. Hendrickson(5), Edward L. Brown(5), David A. Matthews(4), James W. Meador(4), Susan L. Binford(4), Dorothy M. DeLisle(4), Stephen T. Worland(4), Karen A. Maegley(4), Vladimir J. Basus(4), Martin Billeter(4), John Wickersham(3), Zdeněk Hostomský(3)