Susan L. Binford

Pfizer (United States) — United States

Medicine · Health Sciences

14h-index1.6kcitations20works0.02yr avg
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Research Topics

Viral Infections and Immunology Research(14), Respiratory viral infections research(8), RNA and protein synthesis mechanisms(5), Synthesis and Biological Evaluation(3), HIV Research and Treatment(2)

Publications20 total

Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase
Antimicrobial Agents and Chemotherapy·2009· 75 citedOpen Access
In Vitro Resistance Study of Rupintrivir, a Novel Inhibitor of Human Rhinovirus 3C Protease
Antimicrobial Agents and Chemotherapy·2007· 67 citedOpen Access
Development of Novel Cell Lines for the Detection and Quantification of Herpesvirus Replication
Antiviral Research·2007Open Access
In vitro selection of mutations in human immunodeficiency virus type 1 reverse transcriptase that confer resistance to capravirine, a novel nonnucleoside reverse transcriptase inhibitor
Antiviral Research·2006· 22 cited
In Vitro Antiviral Activity and Single-Dose Pharmacokinetics in Humans of a Novel, Orally Bioavailable Inhibitor of Human Rhinovirus 3C Protease
Antimicrobial Agents and Chemotherapy·2005· 133 citedOpen Access
Conservation of Amino Acids in Human Rhinovirus 3C Protease Correlates with Broad-Spectrum Antiviral Activity of Rupintrivir, a Novel Human Rhinovirus 3C Protease Inhibitor
Antimicrobial Agents and Chemotherapy·2005· 156 citedOpen Access
Substituted Benzamide Inhibitors of Human Rhinovirus 3C Protease:  Structure-Based Design, Synthesis, and Biological Evaluation
Journal of Medicinal Chemistry·2000· 52 citedOpen Access
Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors
Bioorganic & Medicinal Chemistry Letters·2000· 43 cited
In Vitro Antiviral Activity of AG7088, a Potent Inhibitor of Human Rhinovirus 3C Protease
Antimicrobial Agents and Chemotherapy·1999· 223 citedOpen Access
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
Proceedings of the National Academy of Sciences·1999· 316 cited
Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids
Bioorganic & Medicinal Chemistry Letters·1999· 25 cited
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 1. Michael Acceptor Structure−Activity Studies
Journal of Medicinal Chemistry·1998· 92 cited
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 2. Peptide Structure−Activity Studies
Journal of Medicinal Chemistry·1998· 111 citedOpen Access
Tripeptide Aldehyde Inhibitors of Human Rhinovirus 3C Protease:  Design, Synthesis, Biological Evaluation, and Cocrystal Structure Solution of P<sub>1</sub> Glutamine Isosteric Replacements
Journal of Medicinal Chemistry·1998· 88 citedOpen Access
ChemInform Abstract: Design, Synthesis, and Evaluation of Nonpeptidic Inhibitors of Human Rhinovirus 3C Protease.
ChemInform·1997
Rhinovirus 3C protease inhibitors are efficacious against several related picornaviruses
Antiviral Research·1997· 1 cited
In vitro isolation and characterization of a human rhinovirus variant resistant to a 3C protease inhibitor
Antiviral Research·1997
Evaluation of the antiviral activity and cytotoxicity of peptidic inhibitors of human rhinovirus 3C protease, a novel target for antiviral intervention
Antiviral Research·1997· 7 cited
Comparison of human cytomegalovirus (HCMV) protease sequences among laboratory strains and seven clinical isolates
Antiviral Research·1997· 4 cited
Design, Synthesis, and Evaluation of Nonpeptidic Inhibitors of Human Rhinovirus 3C Protease
Journal of Medicinal Chemistry·1996· 145 citedOpen Access

Frequent Co-authors

Amy K. Patick(18), Shella A. Fuhrman(14), David A. Matthews(12), James W. Meador(12), Stephen T. Worland(11), Rose Ann Ferre(9), Edward L. Brown(9), L S Zalman(7), Clifford E. Ford(7), Peter S. Dragovich(6), Thomas J. Prins(6), Ru Zhou(6), Jayashree Tikhe(6), Dorothy M. DeLisle(6), Stephen E. Webber(6), Thomas F. Hendrickson(5), M. A. Brothers(5), S. E. Webber(4), Robert A. Love(4), Joseph Marakovits(4)