Thomas F. Hendrickson

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index9.6kcitations36works0.02yr avg
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Research Topics

RNA and protein synthesis mechanisms(7), Viral Infections and Immunology Research(7), Computational Drug Discovery Methods(5), Spectroscopy and Quantum Chemical Studies(5), Protein Structure and Dynamics(4)

Publications36 total

Design, Structure–Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990
Journal of Medicinal Chemistry·2014· 27 citedOpen Access
Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2)
Bioorganic & Medicinal Chemistry Letters·2013· 49 cited
Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors
Bioorganic & Medicinal Chemistry Letters·2012· 29 citedOpen Access
Epigenetic Drug Discovery: Targeting DNA Methyltransferases
SLAS DISCOVERY·2011· 156 citedOpen Access
Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer
ACS Medicinal Chemistry Letters·2011· 248 citedOpen Access
Identification and structure–activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 30 citedOpen Access
Synthesis and in Vitro and in Vivo Evaluation of Phosphoinositide-3-kinase Inhibitors
ACS Medicinal Chemistry Letters·2010· 30 citedOpen Access
Structure-Based Design of a Parallel Synthetic Array Directed Toward the Discovery of Irreversible Inhibitors of Human Rhinovirus 3C Protease
Journal of Medicinal Chemistry·2002· 37 citedOpen Access
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 6. Structure−Activity Studies of Orally Bioavailable, 2-Pyridone-Containing Peptidomimetics
Journal of Medicinal Chemistry·2002· 140 citedOpen Access
Substituted Benzamide Inhibitors of Human Rhinovirus 3C Protease:  Structure-Based Design, Synthesis, and Biological Evaluation
Journal of Medicinal Chemistry·2000· 52 citedOpen Access
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
Proceedings of the National Academy of Sciences·1999· 316 cited
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P<sub>1</sub> Lactam Moieties as <scp>l</scp>-Glutamine Replacements
Journal of Medicinal Chemistry·1999· 189 citedOpen Access
Interaction of a Novel GDP Exchange Inhibitor with the Ras Protein
Biochemistry·1998· 48 cited
Tripeptide Aldehyde Inhibitors of Human Rhinovirus 3C Protease:  Design, Synthesis, Biological Evaluation, and Cocrystal Structure Solution of P<sub>1</sub> Glutamine Isosteric Replacements
Journal of Medicinal Chemistry·1998· 88 citedOpen Access
DATABASESEARCHINGUSING PROTEIN CRYSTAL STRUCTURESAND MOLECULAR DOCKING PROCEDURES
1998
Computational Tools for Structure Based Drug Design
1998· 1 cited
Database Searching using Protein Crystal Structures and Molecular Docking Procedures
1998
Backbone entropy of loops as a measure of their flexibility: Application to a Ras protein simulated by molecular dynamics
Proteins Structure Function and Bioinformatics·1997
Backbone entropy of loops as a measure of their flexibility: Application to a Ras protein simulated by molecular dynamics
Proteins Structure Function and Bioinformatics·1997· 17 cited
ChemInform Abstract: Design, Synthesis, and Evaluation of Nonpeptidic Inhibitors of Human Rhinovirus 3C Protease.
ChemInform·1997
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Frequent Co-authors

Shella A. Fuhrman(9), Edward L. Brown(9), David A. Matthews(8), Amy K. Patick(8), James W. Meador(8), Rose Ann Ferre(8), Stephen T. Worland(8), Robert A. Moss(8), Robert A. Love(5), Susan L. Binford(5), Dorothy M. DeLisle(5), W. Clark Still(4), Peter S. Dragovich(4), Clifford E. Ford(4), Shanti Swarup(4), L S Zalman(3), Thomas J. Prins(3), Ru Zhou(3), Jayashree Tikhe(3), Sabina Pecchi(3)