Thomas J. Prins

Medicine · Health Sciences

18h-index1.9kcitations26works0.02yr avg
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Research Topics

Viral Infections and Immunology Research(12), Chemical Synthesis and Analysis(7), Synthesis and Biological Evaluation(5), Monoclonal and Polyclonal Antibodies Research(4), Organometallic Complex Synthesis and Catalysis(3)

Publications26 total

Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma
Bioorganic & Medicinal Chemistry Letters·2010· 27 citedOpen Access
An optical thin film assay incorporating rhinovirus protease inhibitors as detector reagents
Antiviral Research·2003
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 8. Pharmacological Optimization of Orally Bioavailable 2-Pyridone-Containing Peptidomimetics
Journal of Medicinal Chemistry·2003· 113 cited
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 6. Structure−Activity Studies of Orally Bioavailable, 2-Pyridone-Containing Peptidomimetics
Journal of Medicinal Chemistry·2002· 140 citedOpen Access
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. Part 7: Structure–Activity Studies of Bicyclic 2-Pyridone-Containing Peptidomimetics
Bioorganic & Medicinal Chemistry Letters·2002· 78 cited
Synthesis of an Optically Active, Bicyclic 2-Pyridone Dipeptide Mimetic
The Journal of Organic Chemistry·2002· 21 cited
Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors
Bioorganic & Medicinal Chemistry Letters·2001· 16 cited
Inhibition of Human Rhinovirus-Induced Cytokine Production by AG7088, a Human Rhinovirus 3C Protease Inhibitor
Antimicrobial Agents and Chemotherapy·2000· 58 cited
Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors
Bioorganic & Medicinal Chemistry Letters·2000· 43 cited
In Vitro Antiviral Activity of AG7088, a Potent Inhibitor of Human Rhinovirus 3C Protease
Antimicrobial Agents and Chemotherapy·1999· 223 citedOpen Access
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
Proceedings of the National Academy of Sciences·1999· 316 cited
Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids
Bioorganic & Medicinal Chemistry Letters·1999· 25 cited
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P<sub>1</sub> Lactam Moieties as <scp>l</scp>-Glutamine Replacements
Journal of Medicinal Chemistry·1999· 189 citedOpen Access
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 3. Structure−Activity Studies of Ketomethylene-Containing Peptidomimetics
Journal of Medicinal Chemistry·1999· 68 citedOpen Access
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 1. Michael Acceptor Structure−Activity Studies
Journal of Medicinal Chemistry·1998· 92 cited
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 2. Peptide Structure−Activity Studies
Journal of Medicinal Chemistry·1998· 111 citedOpen Access
Formal, Stereoselective Synthesis of Hydroxyethylene Dipeptide Isosteres Utilizing Pseudoephedrine Amides
The Journal of Organic Chemistry·1997· 16 cited
Structure-Based Design of Novel, Urea-Containing FKBP12 Inhibitors
Journal of Medicinal Chemistry·1996· 61 citedOpen Access
ChemInform Abstract: Palladium‐Catalyzed, Regioselective Reduction of 1,2‐Epoxides by Ammonium Formate.
ChemInform·1995
Palladium Catalyzed, Regioselective Reduction of 1,2-Epoxides by Ammonium Formate
The Journal of Organic Chemistry·1995· 51 cited
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Frequent Co-authors

Peter S. Dragovich(19), Ru Zhou(17), Amy K. Patick(14), Shella A. Fuhrman(13), Stephen T. Worland(13), David A. Matthews(12), James W. Meador(12), Rose Ann Ferre(11), Edward L. Brown(10), L S Zalman(8), Clifford E. Ford(7), Joseph Marakovits(6), Susan L. Binford(6), Stephen E. Webber(6), Caroline A. Lee(5), Jayashree Tikhe(4), Fausto C. Maldonado(4), Thomas F. Hendrickson(3), M. A. Brothers(3), Dorothy M. DeLisle(3)