Adele Cooney

Medicine · Health Sciences

21h-index4.0kcitations27works0.02yr avg
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Research Topics

Lysosomal Storage Disorders Research(11), Parkinson's Disease Mechanisms and Treatments(5), Carbohydrate Chemistry and Synthesis(5), Calcium signaling and nucleotide metabolism(5), Cellular transport and secretion(4)

Publications27 total

Implications for neuronal degene Pick type C disease
2016
The serotonin aldehyde, 5-HIAL, oligomerizes alpha-synuclein
Neuroscience Letters·2015· 23 cited
Rotenone decreases intracellular aldehyde dehydrogenase activity: implications for the pathogenesis of Parkinson's disease
Journal of Neurochemistry·2015· 45 citedOpen Access
Benomyl, Aldehyde Dehydrogenase, DOPAL, and the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson’s Disease
Chemical Research in Toxicology·2014· 76 citedOpen Access
Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein
Neuroscience Letters·2014· 69 citedOpen Access
Vesicular uptake blockade generates the toxic dopamine metabolite 3,4‐dihydroxyphenylacetaldehyde in <scp>PC</scp>12 cells: relevance to the pathogenesis of Parkinson's disease
Journal of Neurochemistry·2012· 80 citedOpen Access
Prediction of response of mutated alpha-galactosidase A to a pharmacological chaperone
Pharmacogenetics and Genomics·2008· 43 citedOpen Access
Screening for pharmacological chaperones in Fabry disease
Biochemical and Biophysical Research Communications·2007· 52 citedOpen Access
The ABCA1 Transporter Modulates Late Endocytic Trafficking
Journal of Biological Chemistry·2004· 195 citedOpen Access
Transfer of a mitochondrial DNA fragment toMCOLN1 causes an inherited case of mucolipidosis IV
Human Mutation·2004· 92 cited
Cellular Localization and Trafficking of the Human ABCA1 Transporter
Journal of Biological Chemistry·2001· 327 citedOpen Access
Cessation of rapid late endosomal tubulovesicular trafficking in Niemann–Pick type C1 disease
Proceedings of the National Academy of Sciences·2001· 146 citedOpen Access
Sterol-modulated Glycolipid Sorting Occurs in Niemann-Pick C1 Late Endosomes
Journal of Biological Chemistry·2001· 111 citedOpen Access
Cyclopamine Inhibition of Sonic Hedgehog Signal Transduction Is Not Mediated through Effects on Cholesterol Transport
Developmental Biology·2000· 98 cited
Mucolipidosis IV consists of one complementation group
Proceedings of the National Academy of Sciences·1999· 26 cited
The Niemann-Pick C1 Protein Resides in a Vesicular Compartment Linked to Retrograde Transport of Multiple Lysosomal Cargo
Journal of Biological Chemistry·1999· 374 citedOpen Access
Localization of Niemann–Pick C1 protein in astrocytes: Implications for neuronal degeneration in Niemann– Pick type C disease
Proceedings of the National Academy of Sciences·1999· 176 cited
Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis
Science·1997· 1.5k cited
Substantial narrowing of the Niemann–Pick C candidate interval by yeast artificial chromosome complementation
Proceedings of the National Academy of Sciences·1997· 28 citedOpen Access
Intracellular Trafficking of Cholesterol Monitored with a Cyclodextrin
Journal of Biological Chemistry·1996· 362 citedOpen Access
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Frequent Co-authors

Peter G. Pentchev(10), Edward B. Neufeld(8), Nancy K. Dwyer(7), Roscoe O. Brady(7), E. Joan Blanchette‐Mackie(6), Christine R. Kaneski(5), David S. Goldstein(5), Yunden Jinsmaa(5), Marcella Comly(4), Shutish C. Patel(4), Calvin F. Roff(4), Marcy Comly(4), Ehud Goldin(4), Raphael Schiffmann(4), Yehonatan Sharabi(4), Eugene D. Carstea(3), Jill A. Morris(3), Marie T. Vanier(3), Sundar Suresh(3), Mei Zhang(3)