Roscoe O. Brady

Beth Israel Deaconess Medical Center — United States

Medicine · Health Sciences

86h-index23.8kcitations302works0.32yr avg
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Research Topics

Lysosomal Storage Disorders Research(229), Carbohydrate Chemistry and Synthesis(66), Cellular transport and secretion(64), Glycosylation and Glycoproteins Research(49), Glycogen Storage Diseases and Myoclonus(38)

Publications302 total

HSD54 Guideline-Driven Off-Label Oncology Use: The Role of Clinical Evidence and Reimbursement Dynamics in the EU4+UK, Switzerland, and Canada
Value in Health·2025
Defining and Engaging a Novel rTMS Target for Nicotine Craving in Psychotic Disorders
2025· 1 citedOpen Access
Antidepressant Effects of TMS are Linked to Orbitofrontal Cortex
Transcranial magnetic stimulation .·2025Open Access
Low-Dose Testosterone Augmentation for Antidepressant-Resistant Major Depressive Disorder in Women: An 8-Week Randomized Placebo-Controlled Study
American Journal of Psychiatry·2020· 30 citedOpen Access
Cerebellar-Cortical Disconnectivity Causes Cognitive Dysfunction in Psychotic Disorders
Biological Psychiatry·2020· 1 cited
Should This Patient Receive an Antidepressant?
Annals of Internal Medicine·2017· 1 cited
Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A
Stem Cells Translational Medicine·2016· 32 citedOpen Access
521. Platelets Transfusion New Role as Brain Therapeutics for Acute Neuronopathic Gaucher Disease
Molecular Therapy·2016Open Access
A prospective 10year study of individualized, intensified enzyme replacement therapy in advanced Fabry disease
Molecular Genetics and Metabolism·2015· 2 cited
Mutant glucocerebrosidase in Gaucher disease recruits Hsp27 to the Hsp90 chaperone complex for proteasomal degradation
Proceedings of the National Academy of Sciences·2015· 28 citedOpen Access
A Short Synthetic Peptide Mimetic of Apolipoprotein A1 Mediates Cholesterol and Globotriaosylceramide Efflux from Fabry Fibroblasts
JIMD Reports·2015· 9 citedOpen Access
Targeting Glucocerebrosidase to Macrophages for Effective Treatment of Patients with Gaucher Disease: Setting the Paradigm of a “Fit for Purpose” Approach to Enzyme Replacement Therapy
AAPS advances in the pharmaceutical sciences series·2015
Normalization and Improvement of CNS Deficits in Mice With Hurler Syndrome After Long-term Peripheral Delivery of BBB-targeted Iduronidase
Molecular Therapy·2014· 21 citedOpen Access
Glucocerebrosidase 2 gene deletion rescues type 1 Gaucher disease
Proceedings of the National Academy of Sciences·2014· 104 citedOpen Access
Platelets are efficient and protective depots for storage, distribution, and delivery of lysosomal enzyme in mice with Hurler Syndrome
Proceedings of the National Academy of Sciences·2014· 16 citedOpen Access
Position statement: National Gaucher Foundation Medical Advisory Board, January 7, 2014
American Journal of Hematology·2014· 8 cited
Abnormal intracellular calcium handling: a key pathogenic and therapeutic target of the cardiac manifestations in Fabry disease
Molecular Genetics and Metabolism·2014· 1 cited
Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones
Proceedings of the National Academy of Sciences·2013· 43 citedOpen Access
<sup>99m</sup>Tc-Sestamibi Scintigraphy to Monitor the Long-Term Efficacy of Enzyme Replacement Therapy on Bone Marrow Infiltration in Patients with Gaucher Disease
Journal of Nuclear Medicine·2013· 5 citedOpen Access
Therapy for Neuronopathic Lysosomal Storage Diseases
2013
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Frequent Co-authors

Peter G. Pentchev(11), Raphael Schiffmann(7), Gary J. Murray(6), E. Joan Blanchette‐Mackie(5), Andrew E. Gal(5), Jane M. Quirk(5), Marcella Comly(4), Nancy K. Dwyer(4), Edward B. Neufeld(4), Norman W. Barton(4), Howard S. Kruth(4), Samuel Gurin(4), Adele Cooney(3), Kousaku Ohno(3), James M. Dambrosia(3), Suvimol Hill(3), Roy M. Bradley(3), Gheona Altarescu(3), David J. Shapiro(3), Shutish C. Patel(3)