Hilda H. Slunt

Allen Institute for Brain Science — United States

Medicine · Health Sciences

33h-index9.8kcitations51works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(27), Prion Diseases and Protein Misfolding(13), Genetic Neurodegenerative Diseases(7), Cholinesterase and Neurodegenerative Diseases(6), Computational Drug Discovery Methods(4)

Publications51 total

Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice
Journal of Biological Chemistry·2007· 116 citedOpen Access
Investigation of RNA interference to suppress expression of full-length and fragment human huntingtin
NeuroMolecular Medicine·2007· 6 cited
Investigation of RNA interference to suppress expression of full-length and fragment human huntingtin
NeuroMolecular Medicine·2007
Characterization of Huntingtin Pathologic Fragments in Human Huntington Disease, Transgenic Mice, and Cell Models
Journal of Neuropathology & Experimental Neurology·2007· 88 citedOpen Access
Disease-associated Mutations at Copper Ligand Histidine Residues of Superoxide Dismutase 1 Diminish the Binding of Copper and Compromise Dimer Stability
Journal of Biological Chemistry·2006· 53 citedOpen Access
Persistent Amyloidosis following Suppression of Aβ Production in a Transgenic Model of Alzheimer Disease
PLoS Medicine·2005· 251 citedOpen Access
Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA
Neurobiology of Disease·2005· 106 citedOpen Access
[O2‐03‐01]: Environmental enrichment mitigates cognitive deficits in APP/PS1 transgenic mice
Alzheimer s & Dementia·2005· 2 citedOpen Access
Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease
Journal of Neuroscience·2005· 514 citedOpen Access
Vignettes
American Journal of Alzheimer s Disease & Other Dementias®·2005Open Access
P2-038 Inhibition of beta-amyloid production and clearance of senile plaques in transgenic mice
Neurobiology of Aging·2004
Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice
Human Molecular Genetics·2004· 102 citedOpen Access
APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1
Neurobiology of Aging·2004· 172 cited
Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature
Human Molecular Genetics·2003· 307 citedOpen Access
Expression of stabilized β-catenin in differentiated neurons of transgenic mice does not result in tumor formation
BMC Cancer·2002· 22 citedOpen Access
Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice
Neurobiology of Aging·2002· 21 cited
Multiple Effects of Aspartate Mutant Presenilin 1 on the Processing and Trafficking of Amyloid Precursor Protein
Journal of Biological Chemistry·2001· 102 citedOpen Access
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies
Biomolecular Engineering·2001· 822 cited
Tetracycline-controlled expression of presenilin-1 in transgenic mice
Neurobiology of Aging·2000
Nuclear Accumulation of Truncated Atrophin-1 Fragments in a Transgenic Mouse Model of DRPLA
Neuron·1999· 184 citedOpen Access
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Frequent Co-authors

Sangram S. Sisodia(28), David Borchelt(27), Donald L. Price(20), Gopal Thinakaran(18), Neal G. Copeland(14), Nancy A. Jenkins(12), Victoria Gonzales(10), Michael K. Lee(9), Joanna L. Jankowsky(7), Tamara Ratovitski(7), Gopal Thinakaran(5), Tamara Ratovitsky(5), Sam Gandy(5), Frances Davenport(4), Mary Seeger(4), Allan I. Levey(4), Steven G. Younkin(4), Hui Zheng(4), Linda H. Younkin(4), Alena Savonenko(4)