David Borchelt

University of Florida Health — United States

Medicine · Health Sciences

84h-index34.0kcitations316works2.52yr avg
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Research Topics

Alzheimer's disease research and treatments(131), Amyotrophic Lateral Sclerosis Research(102), Prion Diseases and Protein Misfolding(77), Neurogenetic and Muscular Disorders Research(52), Parkinson's Disease Mechanisms and Treatments(42)

Publications316 total

Rigorous evaluation of pathological α-synucleinopathy transmissibility between animals in an experimental model
Acta Neuropathologica Communications·2026Open Access
Fast and slow strains of misfolded mutant superoxide dismutase 1 in familial amyotrophic lateral sclerosis
Acta Neuropathologica Communications·2026Open Access
Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity.
PubMed·2026
Efficient induction of motor neuron disease in transgenic G93A SOD1 mice by prion-like seeding
Prion·2026Open Access
Efficient induction of motor neuron disease in transgenic G93A SOD1 mice by prion-like seeding
Figshare·2026Open Access
Efficient induction of motor neuron disease in transgenic G93A SOD1 mice by prion-like seeding
Figshare·2026Open Access
Assessment of the influence of Apolipoprotein E on the deposition of Arctic Aβ and seeded deposits in knock‐in and transgenic mouse models
Alzheimer s & Dementia·2025Open Access
Comparison of the ApoE allelic variants in the formation of intracerebral Aβ deposits
Neurobiology of Disease·2025Open Access
Acetylation Mimetic and Null Mutations Within the Filament Core of <scp>P301L</scp> Tau Have Varied Effects on Susceptibility to Seeding and Aggregation
Journal of Neurochemistry·2025· 1 cited
Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity
2025Open Access
A combinatorial approach to ALS therapies in the PrP.TDP43-315 model of ALS; complications and tribulations
2024Open Access
Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer’s disease
Cell Reports Medicine·2024· 36 citedOpen Access
Human <i>APOE</i> allelic variants suppress the formation of diffuse and fibrillar Aβ deposits relative to mouse <i>Apoe</i> in transgenic mouse models of Alzheimer amyloidosis
2024Open Access
Acetylation mimetic and null mutations within the filament core of P301L tau have varied effects on susceptibility to seeding and aggregation
2024· 1 citedOpen Access
Correction: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
Molecular Neurodegeneration·2024Open Access
Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer’s Disease
2023· 12 citedOpen Access
Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau
Acta Neuropathologica Communications·2023· 4 citedOpen Access
Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice
Viruses·2023· 3 citedOpen Access
Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis
Acta Neuropathologica Communications·2023· 11 citedOpen Access
Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy
Acta Neuropathologica Communications·2023· 12 citedOpen Access
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Frequent Co-authors

Donald L. Price(19), Sangram S. Sisodia(15), Hilda H. Slunt(11), Neal G. Copeland(10), Michael K. Lee(10), Nancy A. Jenkins(9), Joanna L. Jankowsky(7), Guilian Xu(7), Victoria Gonzales(7), Philip C. Wong(7), Don W. Cleveland(6), Alena Savonenko(5), Steven G. Younkin(4), Tamara Ratovitsky(4), Tamara Ratovitski(4), Gopal Thinakaran(4), Albert Taraboulos(4), Linda H. Younkin(3), Frances Davenport(3), Mary Seeger(3)