Syevda Sirenko

National Institute on Aging — United States

Medicine · Health Sciences

23h-index1.6kcitations56works0.02yr avg
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Research Topics

Cardiac electrophysiology and arrhythmias(48), Ion channel regulation and function(26), Neuroscience and Neural Engineering(25), Cardiomyopathy and Myosin Studies(7), Receptor Mechanisms and Signaling(7)

Publications56 total

Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4
Circulation Arrhythmia and Electrophysiology·2018· 28 citedOpen Access
Species Differences of Calcium Clock Functions in Human, Rabbit and Mouse Pacemaker Cells Recapitulate Species Differences in Heart Rate
Biophysical Journal·2018Open Access
Protein Phosphatase-1 Modulates Basal Spontaneous Beating Rate of Sinoatrial Node Cells (SANC)
Biophysical Journal·2018Open Access
Self-Organization of Functional Coupling between Membrane and Calcium Clock in Arrested Human Sinoatrial Nodal Cells in Response to Camp
Biophysical Journal·2018· 1 citedOpen Access
Mammalian γ2 AMPK regulates intrinsic heart rate
Nature Communications·2017· 56 citedOpen Access
Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells
PLoS ONE·2017· 13 citedOpen Access
P1592Pacemaker clocks become uncoupled to cause asystole: heart's endgame
EP Europace·2017Open Access
Human AC8 Overexpression Increases the Ca 2+ Mediated Ensemble and Imparts Improved Rhythmicity to the Sinoatrial Node In Vivo and Ex Vivo
Biophysical Journal·2017Open Access
Cycling Proteins Generates Robust Rhythmic Local Ca 2+ Releases in Cardiac Pacemaker Cells
2017
CaMKII-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local Ca<sup>2+</sup>releases
American Journal of Physiology-Heart and Circulatory Physiology·2016· 39 citedOpen Access
Ca2+/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function
Journal of Molecular and Cellular Cardiology·2016· 36 citedOpen Access
Electrochemical Na<sup>+</sup> and Ca<sup>2+</sup> gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells
American Journal of Physiology-Heart and Circulatory Physiology·2016· 25 citedOpen Access
Synchronization of Local Calcium Releases (LCRs) in Guinea Pig Single, Isolated SA Node Cells Contributes to Generation of Rhythmic Action Potential-Induced Ca2+ Transients
Biophysical Journal·2016Open Access
Concurrent PDE3 and PDE4 Activation Suppresses Local Ca2+ Releases (LCR) to Regulate Normal Spontaneous Firing of Sinoatrial Node Cells (SANC)
Biophysical Journal·2016Open Access
Cardiac Pacemaker Cell Function at a Super-Resolution Scale of SIM: Distribution of RyRs, Calcium Dynamics, and Numerical Modeling
Biophysical Journal·2016· 2 citedOpen Access
Spontaneous, Local Diastolic Subsarcolemmal Ca2+ Releases (LCRS) in Single Isolated Guinea-PIG Sinoatrial Nodal Cells (SANC) are Linked to Their Spontaneous AP Firing
Biophysical Journal·2016Open Access
Glycoside-Induced Collapse of the Sodium and Calcium Gradients Leads to a Biphasic Effect on Cardiac Cell Pacemaker Function
Biophysical Journal·2015Open Access
Reduced Heart Rate in Mice Harboring an SR Luminal Ca2+ Sensor Mutation (E4872Q) is Linked to Abnormal Ca2+ Release and Pacemaker Function in Isolated Cardiocytes Derived from the Mutant RyR Clone
Biophysical Journal·2015Open Access
Abstract 11932: Distinct Patterns of Ca2+ Cycling Protein Abundance and Phosphorylation Level Facilitate Robust and Rhythmic Local Ca2+ Releases to Regulate Spontaneous Beating of Cardiac Pacemaker Cells
Circulation·2014
Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells
Journal of Molecular and Cellular Cardiology·2014· 43 citedOpen Access
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Frequent Co-authors

Edward G. Lakatta(41), Tatiana M. Vinogradova(20), Victor A. Maltsev(16), Alexey E. Lyashkov(15), Dongmei Yang(13), Bruce D. Ziman(11), Harold A. Spurgeon(9), Björn C. Knollmann(8), Kirill V. Tarasov(8), Yevgeniya Lukyanenko(8), L.А. Maltseva(7), Magdalena Juhaszova(7), Michael D. Stern(6), Yael Yaniv(6), Daniel R. Riordon(5), Ismayil Ahmet(4), Steven J. Sollott(4), Yue Li(4), Oliver Monfredi(4), A. Ruknudin(3)