W.G.J. Hol

Environmental Science · Physical Sciences

17h-index1.3kcitations86works0.02yr avg
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Research Topics

Bacteriophages and microbial interactions(12), Biochemical and Molecular Research(12), Protein Structure and Dynamics(8), Trypanosoma species research and implications(8), Enzyme Structure and Function(8)

Publications86 total

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-[(4R)-6,8-dichloro-1,2,3,4-tetrahydroquinolin-4-yl]-N'-(5-fluoro-3H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1717)
2015
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-[(4R)-6,8-dichloro-3,4-dihydro-2H-chromen-4-yl]-N'-(5-fluoro-1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1709)
2015
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-(3-{[5-chloro-3-(prop-2-en-1-yl)-2-(prop-2-en-1-yloxy)benzyl]amino}propyl)-3-thiophen-3-ylurea (Chem 1475)
2013
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-(3-{[5-chloro-2-hydroxy-3-(prop-2-en-1-yl)benzyl]amino}propyl)-3-thiophen-3-ylurea (Chem 1472)
2013
Structure of the N0 domain of the type II secretin from enterotoxigenic Escherichia coli
2013
Crystal Structure of a parasite tRNA synthetase, ligand-free
2013
Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to PTS1 peptide (10-SKL)
2008
Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Phosphoglucoisomerase (PGI) PTS1 peptide
2008
Crystal structure of a two-domain IdeR-DNA complex crystal form I
2006
Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.5 A resolution with (2-ETHYLPHENYL)METHANOL bound
2005
Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.6 A resolution with 1-METHYLQUINOLIN-2(1H)-ONE bound
2005
Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.7 A resolution with 5-Aminoisoquinoline bound
2005
Crystal Structure of heterodimeric L. donovani topoisomerase I-vanadate-DNA complex
2005
Initial Crystallographic Structural Analysis of a putative HAD/COF-like hydrolase from Plasmodium vivax
2005
Cholera toxin A1 subunit bound to ARF6(Q67L)
2005
Cholera toxin A1 subunit bound to its substrate, NAD+, and its human protein activator, ARF6
2005
Crystal structure of the eukaryotic initiation factor 2B from Leishmania major at 2.1 A resolution
2005· 1 cited
Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.8 A resolution
2005
Cholera holotoxin with an A-subunit Y30S mutation, Crystal form 1
2004
Cholera holotoxin with an A-subunit Y30S mutation, Crystal form 2
2004
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Frequent Co-authors

E.A. Merritt(7), Focco van den Akker(6), James J. Champoux(5), Christophe L. M. J. Verlinde(4), E. Fan(4), Fred R. Opperdoes(4), Mariagrazia Pizza(3), Rino Rappuoli(3), Matthew R. Redinbo(3), Jürgen Bosch(3), Jason C. Pickens(3), Danielle Mitchell(3), Anne Volbeda(2), W. P. J. Gaykema(2), Mario Domenighini(2), Bauke W. Dijkstra(2), Randy J. Read(2), Kor H. Kalk(2), A. Teplyakov(2), Joanne I. Yeh(2)