Alan Sielaff

Biochemistry, Genetics and Molecular Biology · Life Sciences

7h-index98citations11works0.02yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(5), RNA Interference and Gene Delivery(3), RNA and protein synthesis mechanisms(2), Cancer therapeutics and mechanisms(2), DNA Repair Mechanisms(1)

Publications11 total

Angioedema Following tPA Administration for Acute Cerebrovascular Accident
Emergency Medicine·2016· 1 cited
Hx, a Novel Fluorescent, Minor Groove and Sequence Specific Recognition Element: Design, Synthesis, and DNA Binding Properties of <i>p</i>-Anisylbenzimidazole-imidazole/pyrrole-Containing Polyamides
Biochemistry·2011· 27 cited
Soviet Influence in British India: Intelligence and Paranoia within Imperial Government in the Interwar Years
CU Scholar (University of Colorado Boulder)·2011Open Access
Abstract 3521: Pharmacological modulation of Topoisomerase IIα expression and confluence-induced resistance to etoposide by a novel fluorescent HxIP polyamide
Cancer Research·2010
Polyamide Curvature and DNA Sequence Selective Recognition: Use of 4-Aminobenzamide to Adjust Curvature
Medicinal Chemistry·2009· 7 cited
Design, synthesis, biophysical and biological studies of fluorescent Hoechst-polyamide hybrid molecules
UCL Discovery (University College London)·2009
Sequence specific and high affinity recognition of 5′-ACGCGT-3′ by rationally designed pyrrole-imidazole H-pin polyamides: Thermodynamic and structural studies
Bioorganic & Medicinal Chemistry·2008· 16 citedOpen Access
Modifying the N-terminus of polyamides: PyImPyIm has improved sequence specificity over f-ImPyIm
Bioorganic & Medicinal Chemistry·2008· 16 cited
2-Aminopurine/cytosine base pair containing oligonucleotides: Fluorescence spectroscopy studies on DNA–polyamide binding
Biochemical and Biophysical Research Communications·2008· 7 cited
SOLUTION PHASE SYNTHESIS OF IMIDAZOLE- AND PYRROLE-CONTAINING HAIRPIN POLYAMIDES
Heterocyclic Communications·2007· 7 citedOpen Access
Binding of f-PIP, a pyrrole- and imidazole-containing triamide, to the inverted CCAAT box-2 of the topoisomerase IIα promoter and modulation of gene expression in cells
Bioorganic & Medicinal Chemistry Letters·2006· 17 cited

Frequent Co-authors

Hilary Mackay(9), Moses Lee(7), Toni Brown(7), John A. Hartley(6), Laura M. Westrate(5), Jérôme Kluza(5), W. David Wilson(4), Jennifer Ruprich(3), Christopher Tronrud(3), Chrystal D. Bruce(3), C. Caroline O’Hare(3), Binh Nguyen(3), Ryan R. Davis(2), Amanda Ferguson(2), Konstantinos Kiakos(2), Daniel Hochhauser(2), Sameer Chavda(1), Yang Liu(1), Balaji Babu(1), Andrew G. Franks(1)